Tlx controls proliferation and patterning of lateral telencephalic progenitor domains
(2003) In The Journal of Neuroscience 23(33). p.10568-10576- Abstract
- We showed previously that the orphan nuclear receptor Tlx is required for the correct establishment of the pallio-subpallial boundary. Loss of Tlx results in a dorsal expansion of ventral markers (e.g., the homeodomain protein GSH2) into the ventralmost pallial region, i.e., the ventral pallium. We also observed a disproportionate reduction in the size of the Tlx mutant lateral ganglionic eminence (LGE) from embryonic day 14.5 onward. Here we show that this reduction is caused, at least in large part, by a proliferation defect. Interestingly, in Tlx mutants, the LGE derivatives are differentially affected. Although the development of the Tlx mutant striatum is compromised, an apparently normal number of olfactory bulb interneurons are... (More)
- We showed previously that the orphan nuclear receptor Tlx is required for the correct establishment of the pallio-subpallial boundary. Loss of Tlx results in a dorsal expansion of ventral markers (e.g., the homeodomain protein GSH2) into the ventralmost pallial region, i.e., the ventral pallium. We also observed a disproportionate reduction in the size of the Tlx mutant lateral ganglionic eminence (LGE) from embryonic day 14.5 onward. Here we show that this reduction is caused, at least in large part, by a proliferation defect. Interestingly, in Tlx mutants, the LGE derivatives are differentially affected. Although the development of the Tlx mutant striatum is compromised, an apparently normal number of olfactory bulb interneurons are observed. Consistent with this observation, we found that Tlx is required for the normal establishment of the ventral LGE that gives rise to striatal projection neurons. This domain is reduced by the dorsal and ventral expansion of molecular markers normally confined to progenitor domains flanking the ventral LGE. Finally, we investigated possible genetic interactions between Gsh2 and Tlx in lateral telencephalic development. Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/294948
- author
- Stenman, Jan LU ; Wang, B and Campbell, Kenneth LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- SFRP2, Dbx1, dorsal LGE, ventral LGE, pallium, ventral, tailless, subpallium, striatum, NR2E1, GSH2, Neurogenin2, ISL1, Er81, NKX6.2
- in
- The Journal of Neuroscience
- volume
- 23
- issue
- 33
- pages
- 10568 - 10576
- publisher
- Society for Neuroscience
- external identifiers
-
- wos:000186680700012
- scopus:0345305682
- ISSN
- 1529-2401
- language
- English
- LU publication?
- yes
- id
- 7032534d-fb2b-4f2c-a65e-37201ca882e7 (old id 294948)
- alternative location
- http://www.jneurosci.org/cgi/content/abstract/23/33/10568
- date added to LUP
- 2016-04-01 16:48:25
- date last changed
- 2023-10-31 13:35:07
@article{7032534d-fb2b-4f2c-a65e-37201ca882e7, abstract = {{We showed previously that the orphan nuclear receptor Tlx is required for the correct establishment of the pallio-subpallial boundary. Loss of Tlx results in a dorsal expansion of ventral markers (e.g., the homeodomain protein GSH2) into the ventralmost pallial region, i.e., the ventral pallium. We also observed a disproportionate reduction in the size of the Tlx mutant lateral ganglionic eminence (LGE) from embryonic day 14.5 onward. Here we show that this reduction is caused, at least in large part, by a proliferation defect. Interestingly, in Tlx mutants, the LGE derivatives are differentially affected. Although the development of the Tlx mutant striatum is compromised, an apparently normal number of olfactory bulb interneurons are observed. Consistent with this observation, we found that Tlx is required for the normal establishment of the ventral LGE that gives rise to striatal projection neurons. This domain is reduced by the dorsal and ventral expansion of molecular markers normally confined to progenitor domains flanking the ventral LGE. Finally, we investigated possible genetic interactions between Gsh2 and Tlx in lateral telencephalic development. Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity.}}, author = {{Stenman, Jan and Wang, B and Campbell, Kenneth}}, issn = {{1529-2401}}, keywords = {{SFRP2; Dbx1; dorsal LGE; ventral LGE; pallium; ventral; tailless; subpallium; striatum; NR2E1; GSH2; Neurogenin2; ISL1; Er81; NKX6.2}}, language = {{eng}}, number = {{33}}, pages = {{10568--10576}}, publisher = {{Society for Neuroscience}}, series = {{The Journal of Neuroscience}}, title = {{Tlx controls proliferation and patterning of lateral telencephalic progenitor domains}}, url = {{http://www.jneurosci.org/cgi/content/abstract/23/33/10568}}, volume = {{23}}, year = {{2003}}, }