Laminin Isoforms in fetal and adult human adrenal cortex
(2003) In Journal of Clinical Endocrinology and Metabolism 88(10). p.4960-4966- Abstract
- Laminin has been proposed to influence the function of human adrenal cortex. We have studied the distribution of laminin (Ln) chains using immunofluorescence in human fetal and adult adrenal cortex. In the fetal gland Ln alpha2- and alpha5-chains were weakly expressed in the definitive zone, whereas Ln alpha4-, beta1-, and gamma1-chains occurred around vessels. In the adult gland, Ln alpha2-, alpha5-, and gamma1-chains were found in epithelial basement membranes (BM) in all cortical zones, Ln alpha4-chain in vessels, Ln beta1-chain in outer zone, and Ln beta2-chain in the two inner zones of the cortex, respectively. Among the integrins in adult gland, integrin alpha(3)-subunit was confined to basal surfaces of cortical cells, alpha(6) to... (More)
- Laminin has been proposed to influence the function of human adrenal cortex. We have studied the distribution of laminin (Ln) chains using immunofluorescence in human fetal and adult adrenal cortex. In the fetal gland Ln alpha2- and alpha5-chains were weakly expressed in the definitive zone, whereas Ln alpha4-, beta1-, and gamma1-chains occurred around vessels. In the adult gland, Ln alpha2-, alpha5-, and gamma1-chains were found in epithelial basement membranes (BM) in all cortical zones, Ln alpha4-chain in vessels, Ln beta1-chain in outer zone, and Ln beta2-chain in the two inner zones of the cortex, respectively. Among the integrins in adult gland, integrin alpha(3)-subunit was confined to basal surfaces of cortical cells, alpha(6) to vessels, alpha(1) to the stroma, and alpha(2) diffusely to epithelial cells. Lutheran glycoprotein and dystroglycan occurred in the fetal gland diffusely in the definitive zone and throughout the epithelium in the adult. The isoform composition of BM of the adult adrenal gland is distinct, with Ln-2 and -10 in BM of the outer zone and Ln-4 and -11 in BM of the two inner zones. The results suggest that integrin alpha(3)beta(1) and Lutheran are candidate receptors for Ln-10 and -11, whereas dystroglycan probably binds Ln-2 and -4. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/298396
- author
- Virtanen, I ; Korhonen, M ; Petajaniemi, N ; Karhunen, T ; Thornell, LE ; Sorokin, Lydia LU and Konttinen, YT
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 88
- issue
- 10
- pages
- 4960 - 4966
- publisher
- Oxford University Press
- external identifiers
-
- wos:000185906300066
- pmid:14557481
- scopus:0242332754
- pmid:14557481
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2003-030418
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 56df87d4-2e7f-48ff-90a0-96a373f3e756 (old id 298396)
- alternative location
- http://jcem.endojournals.org/cgi/content/abstract/88/10/4960
- date added to LUP
- 2016-04-01 16:08:02
- date last changed
- 2022-01-28 17:33:35
@article{56df87d4-2e7f-48ff-90a0-96a373f3e756, abstract = {{Laminin has been proposed to influence the function of human adrenal cortex. We have studied the distribution of laminin (Ln) chains using immunofluorescence in human fetal and adult adrenal cortex. In the fetal gland Ln alpha2- and alpha5-chains were weakly expressed in the definitive zone, whereas Ln alpha4-, beta1-, and gamma1-chains occurred around vessels. In the adult gland, Ln alpha2-, alpha5-, and gamma1-chains were found in epithelial basement membranes (BM) in all cortical zones, Ln alpha4-chain in vessels, Ln beta1-chain in outer zone, and Ln beta2-chain in the two inner zones of the cortex, respectively. Among the integrins in adult gland, integrin alpha(3)-subunit was confined to basal surfaces of cortical cells, alpha(6) to vessels, alpha(1) to the stroma, and alpha(2) diffusely to epithelial cells. Lutheran glycoprotein and dystroglycan occurred in the fetal gland diffusely in the definitive zone and throughout the epithelium in the adult. The isoform composition of BM of the adult adrenal gland is distinct, with Ln-2 and -10 in BM of the outer zone and Ln-4 and -11 in BM of the two inner zones. The results suggest that integrin alpha(3)beta(1) and Lutheran are candidate receptors for Ln-10 and -11, whereas dystroglycan probably binds Ln-2 and -4.}}, author = {{Virtanen, I and Korhonen, M and Petajaniemi, N and Karhunen, T and Thornell, LE and Sorokin, Lydia and Konttinen, YT}}, issn = {{1945-7197}}, language = {{eng}}, number = {{10}}, pages = {{4960--4966}}, publisher = {{Oxford University Press}}, series = {{Journal of Clinical Endocrinology and Metabolism}}, title = {{Laminin Isoforms in fetal and adult human adrenal cortex}}, url = {{http://dx.doi.org/10.1210/jc.2003-030418}}, doi = {{10.1210/jc.2003-030418}}, volume = {{88}}, year = {{2003}}, }