L-DOPA and graft-induced dyskinesia : different treatment, same story?
(2013) In Experimental Biology and Medicine 238(7). p.32-725- Abstract
One of the well-recognized problems of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) therapy in the treatment of Parkinson's disease is the development of L-DOPA induced dyskinesia. These abnormal movements cause significant disability and narrow the therapeutic window of L-DOPA. Cell transplantation is one of the most promising upcoming therapies for the treatment of Parkinson's disease, and may help alleviate or avoid L-DOPA-induced dyskinesia. However, the more recently acknowledged phenomenon of graft-induced dyskinesia is posing a major obstacle to the success of this treatment. This motor side-effect closely resembles abnormal movements induced by chronic L-DOPA treatment, yet they remain after withdrawal of the medication... (More)
One of the well-recognized problems of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) therapy in the treatment of Parkinson's disease is the development of L-DOPA induced dyskinesia. These abnormal movements cause significant disability and narrow the therapeutic window of L-DOPA. Cell transplantation is one of the most promising upcoming therapies for the treatment of Parkinson's disease, and may help alleviate or avoid L-DOPA-induced dyskinesia. However, the more recently acknowledged phenomenon of graft-induced dyskinesia is posing a major obstacle to the success of this treatment. This motor side-effect closely resembles abnormal movements induced by chronic L-DOPA treatment, yet they remain after withdrawal of the medication indicating their origins lie in the transplant. In this review, we compare these two therapy-induced adverse effects, from the way they manifest in patients to the possible mechanisms underlying their development.
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- author
- Breger, Ludivine S LU and Lane, Emma L LU
- publishing date
- 2013-07
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Cell Transplantation, Disease Models, Animal, Dyskinesias, Humans, Levodopa, Journal Article, Research Support, Non-U.S. Gov't, Review
- in
- Experimental Biology and Medicine
- volume
- 238
- issue
- 7
- pages
- 8 pages
- publisher
- SAGE Publications
- external identifiers
-
- scopus:84884189976
- pmid:23828589
- ISSN
- 1535-3702
- DOI
- 10.1177/1535370213488478
- language
- English
- LU publication?
- no
- id
- 2a1ad6d9-bc9d-4447-af22-48ade3d84b1d
- date added to LUP
- 2016-10-04 13:03:31
- date last changed
- 2024-08-09 19:57:39
@article{2a1ad6d9-bc9d-4447-af22-48ade3d84b1d, abstract = {{<p>One of the well-recognized problems of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) therapy in the treatment of Parkinson's disease is the development of L-DOPA induced dyskinesia. These abnormal movements cause significant disability and narrow the therapeutic window of L-DOPA. Cell transplantation is one of the most promising upcoming therapies for the treatment of Parkinson's disease, and may help alleviate or avoid L-DOPA-induced dyskinesia. However, the more recently acknowledged phenomenon of graft-induced dyskinesia is posing a major obstacle to the success of this treatment. This motor side-effect closely resembles abnormal movements induced by chronic L-DOPA treatment, yet they remain after withdrawal of the medication indicating their origins lie in the transplant. In this review, we compare these two therapy-induced adverse effects, from the way they manifest in patients to the possible mechanisms underlying their development.</p>}}, author = {{Breger, Ludivine S and Lane, Emma L}}, issn = {{1535-3702}}, keywords = {{Animals; Cell Transplantation; Disease Models, Animal; Dyskinesias; Humans; Levodopa; Journal Article; Research Support, Non-U.S. Gov't; Review}}, language = {{eng}}, number = {{7}}, pages = {{32--725}}, publisher = {{SAGE Publications}}, series = {{Experimental Biology and Medicine}}, title = {{L-DOPA and graft-induced dyskinesia : different treatment, same story?}}, url = {{http://dx.doi.org/10.1177/1535370213488478}}, doi = {{10.1177/1535370213488478}}, volume = {{238}}, year = {{2013}}, }