Allergic contact dermatitis caused by 1,6-hexanediol diacrylate in a hospital wristband
(2019) In Contact Dermatitis 81(6). p.446-449- Abstract
Background: 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer. Objectives: To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband. Methods: A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, and pieces of the hospital wristband. Thin-layer chromatography (TLC) was performed with extracts from the wristband and gas chromatography-mass spectrometry was used for chemical analysis. Results: Positive reactions were found to pieces of the wristband, including adhesive rim (+++), inside (+++), and outside (++); to multiple allergens in the... (More)
Background: 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer. Objectives: To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband. Methods: A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, and pieces of the hospital wristband. Thin-layer chromatography (TLC) was performed with extracts from the wristband and gas chromatography-mass spectrometry was used for chemical analysis. Results: Positive reactions were found to pieces of the wristband, including adhesive rim (+++), inside (+++), and outside (++); to multiple allergens in the (meth)acrylates series; and to extracts of the wristband in acetone and ethanol. Chemical analysis of the ethanol extract showed presence of lauryl acrylate and 1,6-HDDA. Patch testing with TLC strips and subsequent chemical analysis showed that the substance causing the strongest reaction was 1,6-HDDA, to which the patient had a confirmed positive patch test reaction. Conclusion: 1,6-HDDA was identified as the culprit allergen responsible for allergic contact dermatitis caused by the hospital wristband.
(Less)
- author
- van Amerongen, Cynthia C.A. ; Dahlin, Jakob LU ; Isaksson, Marléne LU and Schuttelaar, Marie L.A.
- organization
- publishing date
- 2019-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 1,6-hexanediol diacrylate (1,6-HDDA), acrylate, allergic contact dermatitis, CAS no. 13048-33-4, case report, wristband
- in
- Contact Dermatitis
- volume
- 81
- issue
- 6
- pages
- 446 - 449
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:31392731
- scopus:85071294534
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.13378
- language
- English
- LU publication?
- yes
- id
- 2e5337bd-2130-4834-b2d1-feece5241b44
- date added to LUP
- 2019-09-03 08:38:31
- date last changed
- 2024-04-30 19:58:03
@article{2e5337bd-2130-4834-b2d1-feece5241b44,
abstract = {{<p>Background: 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer. Objectives: To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband. Methods: A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, and pieces of the hospital wristband. Thin-layer chromatography (TLC) was performed with extracts from the wristband and gas chromatography-mass spectrometry was used for chemical analysis. Results: Positive reactions were found to pieces of the wristband, including adhesive rim (+++), inside (+++), and outside (++); to multiple allergens in the (meth)acrylates series; and to extracts of the wristband in acetone and ethanol. Chemical analysis of the ethanol extract showed presence of lauryl acrylate and 1,6-HDDA. Patch testing with TLC strips and subsequent chemical analysis showed that the substance causing the strongest reaction was 1,6-HDDA, to which the patient had a confirmed positive patch test reaction. Conclusion: 1,6-HDDA was identified as the culprit allergen responsible for allergic contact dermatitis caused by the hospital wristband.</p>}},
author = {{van Amerongen, Cynthia C.A. and Dahlin, Jakob and Isaksson, Marléne and Schuttelaar, Marie L.A.}},
issn = {{0105-1873}},
keywords = {{1,6-hexanediol diacrylate (1,6-HDDA); acrylate; allergic contact dermatitis; CAS no. 13048-33-4; case report; wristband}},
language = {{eng}},
month = {{01}},
number = {{6}},
pages = {{446--449}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Allergic contact dermatitis caused by 1,6-hexanediol diacrylate in a hospital wristband}},
url = {{http://dx.doi.org/10.1111/cod.13378}},
doi = {{10.1111/cod.13378}},
volume = {{81}},
year = {{2019}},
}