Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes
(2017) In Journal of Diabetes and its Complications 31(1). p.202-208- Abstract
AIMS: Vitamin B12 deficiency could be associated with cardiovascular autonomic neuropathy (CAN) in diabetes patients. We aim to investigate the association between serum levels of vitamin B12 and CAN in type 2 diabetes patients.
METHODS: 469 ambulatory type 2 diabetes patients (mean diabetes duration 10.0years (IQR 5.0;17.0), mean age 59.0years (SD 11.6), 63% men, mean B12 289.0pmol/l (IQR 217;390)) were screened for CAN using three cardiovascular reflex tests, five minute resting heart rate (5min RHR) and heart rate variability indices.
RESULTS: Serum levels of vitamin B12 were significantly lower in patients treated with metformin and/or proton pump inhibitors (PPIs) compared with patients not treated (p<0.001). A... (More)
AIMS: Vitamin B12 deficiency could be associated with cardiovascular autonomic neuropathy (CAN) in diabetes patients. We aim to investigate the association between serum levels of vitamin B12 and CAN in type 2 diabetes patients.
METHODS: 469 ambulatory type 2 diabetes patients (mean diabetes duration 10.0years (IQR 5.0;17.0), mean age 59.0years (SD 11.6), 63% men, mean B12 289.0pmol/l (IQR 217;390)) were screened for CAN using three cardiovascular reflex tests, five minute resting heart rate (5min RHR) and heart rate variability indices.
RESULTS: Serum levels of vitamin B12 were significantly lower in patients treated with metformin and/or proton pump inhibitors (PPIs) compared with patients not treated (p<0.001). A 25pmol/l higher level of vitamin B12 was associated with an odds ratio of the CAN diagnosis of 0.94 (95% CI 0.88; 1.00, p=0.034), an increase in E/I-ratio of 0.21% (95% CI 0.01; 0.43, p=0.038), and a decrease in 5min RHR of 0.25 beats per minute (95% CI -0.47; -0.03, p=0.025).
CONCLUSION: Vitamin B12 may be inversely associated with CAN in patients with type 2 diabetes. Confirmatory studies investigating a causal role of vitamin B12 for the development of diabetic CAN are warranted.
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- author
- Hansen, Christian S ; Jensen, Jan S ; Ridderstråle, Martin LU ; Vistisen, Dorte ; Jørgensen, Marit E and Fleischer, Jesper
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- in
- Journal of Diabetes and its Complications
- volume
- 31
- issue
- 1
- pages
- 202 - 208
- publisher
- Elsevier
- external identifiers
-
- pmid:27638143
- scopus:84994756426
- ISSN
- 1873-460X
- DOI
- 10.1016/j.jdiacomp.2016.08.025
- language
- English
- LU publication?
- no
- id
- 2f613013-1fb0-4193-9903-a9ab12e1faf1
- date added to LUP
- 2016-10-04 16:12:09
- date last changed
- 2024-09-21 00:17:16
@article{2f613013-1fb0-4193-9903-a9ab12e1faf1, abstract = {{<p>AIMS: Vitamin B12 deficiency could be associated with cardiovascular autonomic neuropathy (CAN) in diabetes patients. We aim to investigate the association between serum levels of vitamin B12 and CAN in type 2 diabetes patients.</p><p>METHODS: 469 ambulatory type 2 diabetes patients (mean diabetes duration 10.0years (IQR 5.0;17.0), mean age 59.0years (SD 11.6), 63% men, mean B12 289.0pmol/l (IQR 217;390)) were screened for CAN using three cardiovascular reflex tests, five minute resting heart rate (5min RHR) and heart rate variability indices.</p><p>RESULTS: Serum levels of vitamin B12 were significantly lower in patients treated with metformin and/or proton pump inhibitors (PPIs) compared with patients not treated (p<0.001). A 25pmol/l higher level of vitamin B12 was associated with an odds ratio of the CAN diagnosis of 0.94 (95% CI 0.88; 1.00, p=0.034), an increase in E/I-ratio of 0.21% (95% CI 0.01; 0.43, p=0.038), and a decrease in 5min RHR of 0.25 beats per minute (95% CI -0.47; -0.03, p=0.025).</p><p>CONCLUSION: Vitamin B12 may be inversely associated with CAN in patients with type 2 diabetes. Confirmatory studies investigating a causal role of vitamin B12 for the development of diabetic CAN are warranted.</p>}}, author = {{Hansen, Christian S and Jensen, Jan S and Ridderstråle, Martin and Vistisen, Dorte and Jørgensen, Marit E and Fleischer, Jesper}}, issn = {{1873-460X}}, language = {{eng}}, number = {{1}}, pages = {{202--208}}, publisher = {{Elsevier}}, series = {{Journal of Diabetes and its Complications}}, title = {{Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes}}, url = {{http://dx.doi.org/10.1016/j.jdiacomp.2016.08.025}}, doi = {{10.1016/j.jdiacomp.2016.08.025}}, volume = {{31}}, year = {{2017}}, }