Familial risk of sleep-disordered breathing

Lundkvist, Karin; Sundquist, Kristina; Li, Xinjun; Friberg, Danielle

Familial risk of sleep-disordered breathing

Mark

Lundkvist, Karin ; Sundquist, Kristina ^LU ; Li, Xinjun ^LU and Friberg, Danielle (2012) In Sleep Medicine 13(6). p.668-673

Abstract: Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for boys and... (More); Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for boys and girls with a parent affected by OSAS. Children with OSAS or adenotonsillar or tonsillar hypertrophy without a parent affected by OSAS acted as the reference group (SIR = 1). Results: After accounting for socio-economic status, age, and geographic region, the SIRs of OSAS in boys and girls with a parent affected by OSAS were 3.09 (95% CI 1.83-4.90) and 4.46 (95% CI 2.68-6.98), respectively. The SIRs of adenotonsillar or tonsillar hypertrophy in boys and girls with a parent affected by OSAS were 1.82 (95% CI 1.54-2.14) and 1.56 (95% CI 1.30-1.87), respectively. Conclusion: This study indicates familial clustering of sleep-disordered breathing, which is important information for clinicians. (C) 2012 Elsevier B.V. All rights reserved. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/3001258

author

Lundkvist, Karin ; Sundquist, Kristina ^LU ; Li, Xinjun ^LU and Friberg, Danielle

organization

publishing date

2012

type

Contribution to journal

publication status

published

subject

Public Health, Global Health, Social Medicine and Epidemiology

keywords

Adenotonsillar hypertrophy, Children, Heredity, Hospitalization, Obstructive sleep apnoea, Population-based studies, Sleep-disordered, breathing

in

Sleep Medicine

volume

13

issue

6

pages

668 - 673

publisher

Elsevier

external identifiers

wos:000306304700019
scopus:84861925956
pmid:22538192

ISSN

1878-5506

DOI

10.1016/j.sleep.2012.01.014

language

English

LU publication?

yes

id

977ded8f-abe4-47fd-baeb-e6278d525acf (old id 3001258)

date added to LUP

2016-04-01 10:53:39

date last changed

2022-01-26 03:34:32

@article{977ded8f-abe4-47fd-baeb-e6278d525acf,
  abstract     = {{Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for boys and girls with a parent affected by OSAS. Children with OSAS or adenotonsillar or tonsillar hypertrophy without a parent affected by OSAS acted as the reference group (SIR = 1). Results: After accounting for socio-economic status, age, and geographic region, the SIRs of OSAS in boys and girls with a parent affected by OSAS were 3.09 (95% CI 1.83-4.90) and 4.46 (95% CI 2.68-6.98), respectively. The SIRs of adenotonsillar or tonsillar hypertrophy in boys and girls with a parent affected by OSAS were 1.82 (95% CI 1.54-2.14) and 1.56 (95% CI 1.30-1.87), respectively. Conclusion: This study indicates familial clustering of sleep-disordered breathing, which is important information for clinicians. (C) 2012 Elsevier B.V. All rights reserved.}},
  author       = {{Lundkvist, Karin and Sundquist, Kristina and Li, Xinjun and Friberg, Danielle}},
  issn         = {{1878-5506}},
  keywords     = {{Adenotonsillar hypertrophy; Children; Heredity; Hospitalization; Obstructive sleep apnoea; Population-based studies; Sleep-disordered; breathing}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{668--673}},
  publisher    = {{Elsevier}},
  series       = {{Sleep Medicine}},
  title        = {{Familial risk of sleep-disordered breathing}},
  url          = {{https://lup.lub.lu.se/search/files/2214192/3124955.pdf}},
  doi          = {{10.1016/j.sleep.2012.01.014}},
  volume       = {{13}},
  year         = {{2012}},
}

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Familial risk of sleep-disordered breathing