Antioxidant secondary metabolites from Geranium lasiopus Boiss. & Heldr.
(2012) In Natural Product Research 26(13). p.1261-1264- Abstract
- Chromatographic studies on the EtOAc soluble portion of the MeOH extract of Geranium lasiopus led to the isolation of eight flavonoids (kaempferol (1), quercetin (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (5), quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (6), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (7) and quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (8)), two simple phenolic compounds (gallic acid (9) and its methyl ester (10)) and a hydrolysable tannin (pusilagin (11)). The structures of the compounds were elucidated by 1- and 2-dimensional NMR... (More)
- Chromatographic studies on the EtOAc soluble portion of the MeOH extract of Geranium lasiopus led to the isolation of eight flavonoids (kaempferol (1), quercetin (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (5), quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (6), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (7) and quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (8)), two simple phenolic compounds (gallic acid (9) and its methyl ester (10)) and a hydrolysable tannin (pusilagin (11)). The structures of the compounds were elucidated by 1- and 2-dimensional NMR techniques (H-1, C-13, COSY, HMBC, HMQC) and ESI-TOF-MS spectrometry. Inhibitory effects on H2O2-induced lipid peroxidation in human red blood cells of the different extracts of G. lasiopus, as well as isolated compounds, were investigated. All tested compounds showed comparable or higher activity than that of ascorbic acid and trolox. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3001289
- author
- Sohretoglu, Didem ; Sakar, Mahmut Koray ; Sabuncuoglu, Suna Atasayar ; Ozgunes, Hilal ; Duman, Hayri and Sterner, Olov LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Geranium lasiopus, Geraniaceae, flavonoids, tannin, antioxidant activity
- in
- Natural Product Research
- volume
- 26
- issue
- 13
- pages
- 1261 - 1264
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000306278100015
- scopus:84864042894
- pmid:21995426
- ISSN
- 1478-6419
- DOI
- 10.1080/14786419.2011.578071
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 253a429b-1f3e-423c-9147-629860cf00d8 (old id 3001289)
- date added to LUP
- 2016-04-01 10:50:57
- date last changed
- 2022-01-26 03:01:00
@article{253a429b-1f3e-423c-9147-629860cf00d8,
abstract = {{Chromatographic studies on the EtOAc soluble portion of the MeOH extract of Geranium lasiopus led to the isolation of eight flavonoids (kaempferol (1), quercetin (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (5), quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (6), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (7) and quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (8)), two simple phenolic compounds (gallic acid (9) and its methyl ester (10)) and a hydrolysable tannin (pusilagin (11)). The structures of the compounds were elucidated by 1- and 2-dimensional NMR techniques (H-1, C-13, COSY, HMBC, HMQC) and ESI-TOF-MS spectrometry. Inhibitory effects on H2O2-induced lipid peroxidation in human red blood cells of the different extracts of G. lasiopus, as well as isolated compounds, were investigated. All tested compounds showed comparable or higher activity than that of ascorbic acid and trolox.}},
author = {{Sohretoglu, Didem and Sakar, Mahmut Koray and Sabuncuoglu, Suna Atasayar and Ozgunes, Hilal and Duman, Hayri and Sterner, Olov}},
issn = {{1478-6419}},
keywords = {{Geranium lasiopus; Geraniaceae; flavonoids; tannin; antioxidant activity}},
language = {{eng}},
number = {{13}},
pages = {{1261--1264}},
publisher = {{Taylor & Francis}},
series = {{Natural Product Research}},
title = {{Antioxidant secondary metabolites from Geranium lasiopus Boiss. & Heldr.}},
url = {{http://dx.doi.org/10.1080/14786419.2011.578071}},
doi = {{10.1080/14786419.2011.578071}},
volume = {{26}},
year = {{2012}},
}