Osteocalcin, glucose metabolism, lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese.
(2013) In Diabetic Medicine 30(3). p.309-317- Abstract
- Aim:
To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects.
Methods:
We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined.
Results:
Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (P... (More) - Aim:
To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects.
Methods:
We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined.
Results:
Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (P < 0.001). Serum osteocalcin levels of participants with self-reported cardiovascular disease were significantly lower (P = 0.044) than those without. In men, serum osteocalcin levels of participants with the metabolic syndrome were significantly lower than those without the metabolic syndrome (P = 0.036). Serum osteocalcin correlated negatively with fasting serum insulin, homeostasis model assessment of insulin resistance, alanine aminotransferase, triglycerides and total cholesterol, and positively with homeostasis model assessment of β-cell function in both men and post-menopausal women (all P < 0.05). In men, serum osteocalcin correlated negatively with BMI, diastolic blood pressure, fasting plasma glucose and 2-h oral glucose tolerance test glucose after adjustment for age (all P < 0.05). In post-menopausal women, serum osteocalcin correlated negatively with waist-hip ratio, LDL cholesterol and C-reactive protein, and positively with adiponectin (all P < 0.05). Serum osteocalcin was not associated with CXC chemokine ligand 5 level (P > 0.05). Alanine aminotransferase was an independent predictor of serum osteocalcin in both men and post-menopausal women (both P < 0.001). Adiponectin was an independent predictor of serum osteocalcin in post-menopausal women (P = 0.011). Serum osteocalcin was an independent predictor of homeostasis model assessment of β-cell function in both genders (both P < 0.05).
Conclusions:
Serum total osteocalcin was closely associated with glucose and lipid metabolism in both Chinese men and post-menopausal women. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3047309
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetic Medicine
- volume
- 30
- issue
- 3
- pages
- 309 - 317
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000315339300016
- pmid:22913521
- scopus:84874185722
- pmid:22913521
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2012.03769.x
- language
- English
- LU publication?
- yes
- id
- b452b4db-4b7e-40ab-99cf-bb00694dfdc0 (old id 3047309)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22913521?dopt=Abstract
- date added to LUP
- 2016-04-01 09:48:03
- date last changed
- 2022-05-31 23:02:55
@article{b452b4db-4b7e-40ab-99cf-bb00694dfdc0, abstract = {{Aim: <br/><br> To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects. <br/><br> <br/><br> Methods: <br/><br> We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined. <br/><br> <br/><br> Results: <br/><br> Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (P < 0.001). Serum osteocalcin levels of participants with self-reported cardiovascular disease were significantly lower (P = 0.044) than those without. In men, serum osteocalcin levels of participants with the metabolic syndrome were significantly lower than those without the metabolic syndrome (P = 0.036). Serum osteocalcin correlated negatively with fasting serum insulin, homeostasis model assessment of insulin resistance, alanine aminotransferase, triglycerides and total cholesterol, and positively with homeostasis model assessment of β-cell function in both men and post-menopausal women (all P < 0.05). In men, serum osteocalcin correlated negatively with BMI, diastolic blood pressure, fasting plasma glucose and 2-h oral glucose tolerance test glucose after adjustment for age (all P < 0.05). In post-menopausal women, serum osteocalcin correlated negatively with waist-hip ratio, LDL cholesterol and C-reactive protein, and positively with adiponectin (all P < 0.05). Serum osteocalcin was not associated with CXC chemokine ligand 5 level (P > 0.05). Alanine aminotransferase was an independent predictor of serum osteocalcin in both men and post-menopausal women (both P < 0.001). Adiponectin was an independent predictor of serum osteocalcin in post-menopausal women (P = 0.011). Serum osteocalcin was an independent predictor of homeostasis model assessment of β-cell function in both genders (both P < 0.05). <br/><br> <br/><br> Conclusions: <br/><br> Serum total osteocalcin was closely associated with glucose and lipid metabolism in both Chinese men and post-menopausal women. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.}}, author = {{Ling, Chen and Li, Qi and Yang, Z and Ye, Z and Huang, Yuan and He, M and Wen, J and Wang, X and Lu, B and Hu, J and Liu, Connor and Ling, Charlotte and Qu, S and Hu, R}}, issn = {{1464-5491}}, language = {{eng}}, number = {{3}}, pages = {{309--317}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetic Medicine}}, title = {{Osteocalcin, glucose metabolism, lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese.}}, url = {{http://dx.doi.org/10.1111/j.1464-5491.2012.03769.x}}, doi = {{10.1111/j.1464-5491.2012.03769.x}}, volume = {{30}}, year = {{2013}}, }