Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau
(2003) In Scandinavian Journal of Infectious Diseases 35(4). p.265-272- Abstract
- The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1 + 2 was... (More)
- The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1 + 2 was 8.6/100 person-years (py) ( rate ratio 6.2 compared with HIV-negative controls, 95% confidence interval 2.7 - 14.2, p< 0.001), and the progression rate to stage 4, i.e. acquired immunodeficiency syndrome ( AIDS), was 2.1/100 py. HIV-2-positive people in stage 3 at inclusion progressed to AIDS at a rate of 16.9/100 py. CD4% &LE; 20 was found to be a significant prognostic marker for progression to stage 4, both from stage 1 + 2 and from stage 3. The clinical progression in this cohort of HIV-2-infected subjects was generally lower than that in HIV-1-positive cohorts. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/309971
- author
- Norrgren, Hans LU ; Da Silva, Z ; Biague, A ; Andersson, S and Biberfeld, G
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Infectious Diseases
- volume
- 35
- issue
- 4
- pages
- 265 - 272
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:12839157
- wos:000183000300012
- scopus:0038760843
- ISSN
- 1651-1980
- DOI
- 10.1080/00365540310000210
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000)
- id
- 73b948a3-0254-40a5-b35b-a38666c5d9db (old id 309971)
- date added to LUP
- 2016-04-01 15:53:06
- date last changed
- 2022-01-28 07:44:14
@article{73b948a3-0254-40a5-b35b-a38666c5d9db, abstract = {{The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1 + 2 was 8.6/100 person-years (py) ( rate ratio 6.2 compared with HIV-negative controls, 95% confidence interval 2.7 - 14.2, p< 0.001), and the progression rate to stage 4, i.e. acquired immunodeficiency syndrome ( AIDS), was 2.1/100 py. HIV-2-positive people in stage 3 at inclusion progressed to AIDS at a rate of 16.9/100 py. CD4% &LE; 20 was found to be a significant prognostic marker for progression to stage 4, both from stage 1 + 2 and from stage 3. The clinical progression in this cohort of HIV-2-infected subjects was generally lower than that in HIV-1-positive cohorts.}}, author = {{Norrgren, Hans and Da Silva, Z and Biague, A and Andersson, S and Biberfeld, G}}, issn = {{1651-1980}}, language = {{eng}}, number = {{4}}, pages = {{265--272}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Infectious Diseases}}, title = {{Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau}}, url = {{http://dx.doi.org/10.1080/00365540310000210}}, doi = {{10.1080/00365540310000210}}, volume = {{35}}, year = {{2003}}, }