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Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.

Adler, Belinda LU ; Laurell, Thomas LU and Ekström, Simon LU (2012) In Electrophoresis 33(21). p.3143-3150
Abstract
The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Electrophoresis
volume
33
issue
21
pages
3143 - 3150
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:22949121
  • wos:000310476600004
  • scopus:84868014084
ISSN
0173-0835
DOI
10.1002/elps.201200134
language
English
LU publication?
yes
id
418495ae-6941-4363-8a9e-9fa6c88a6662 (old id 3124345)
date added to LUP
2016-04-01 11:03:08
date last changed
2022-01-26 04:59:33
@article{418495ae-6941-4363-8a9e-9fa6c88a6662,
  abstract     = {{The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.}},
  author       = {{Adler, Belinda and Laurell, Thomas and Ekström, Simon}},
  issn         = {{0173-0835}},
  language     = {{eng}},
  number       = {{21}},
  pages        = {{3143--3150}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Electrophoresis}},
  title        = {{Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.}},
  url          = {{http://dx.doi.org/10.1002/elps.201200134}},
  doi          = {{10.1002/elps.201200134}},
  volume       = {{33}},
  year         = {{2012}},
}