Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.
(2012) In Electrophoresis 33(21). p.3143-3150- Abstract
- The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3124345
- author
- Adler, Belinda LU ; Laurell, Thomas LU and Ekström, Simon LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Electrophoresis
- volume
- 33
- issue
- 21
- pages
- 3143 - 3150
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:22949121
- wos:000310476600004
- scopus:84868014084
- ISSN
- 0173-0835
- DOI
- 10.1002/elps.201200134
- language
- English
- LU publication?
- yes
- id
- 418495ae-6941-4363-8a9e-9fa6c88a6662 (old id 3124345)
- date added to LUP
- 2016-04-01 11:03:08
- date last changed
- 2022-01-26 04:59:33
@article{418495ae-6941-4363-8a9e-9fa6c88a6662, abstract = {{The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.}}, author = {{Adler, Belinda and Laurell, Thomas and Ekström, Simon}}, issn = {{0173-0835}}, language = {{eng}}, number = {{21}}, pages = {{3143--3150}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Electrophoresis}}, title = {{Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.}}, url = {{http://dx.doi.org/10.1002/elps.201200134}}, doi = {{10.1002/elps.201200134}}, volume = {{33}}, year = {{2012}}, }