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Boron neutron capture therapy for glioblastoma multiforme : Clinical studies in Sweden

Capala, J ; Stenstam, BH ; Skold, KS ; Munck af Rosenschöld, Per LU orcid ; Giusti, V ; Persson, C ; Wallin, E ; Brun, A ; Franzen, L and Carlsson, JO , et al. (2003) In Journal of Neuro-Oncology 62(1). p.135-144
Abstract

A boron neutron capture therapy (BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/moderator configurations. One of the resulting neutron beams has been optimized for clinical irradiations with a filter/moderator system that allows easy variation of the neutron spectrum from the thermal to the epithermal energy range. The other beam has been designed to produce a large uniform field of thermal neutrons for radio-biological research. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with... (More)

A boron neutron capture therapy (BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/moderator configurations. One of the resulting neutron beams has been optimized for clinical irradiations with a filter/moderator system that allows easy variation of the neutron spectrum from the thermal to the epithermal energy range. The other beam has been designed to produce a large uniform field of thermal neutrons for radio-biological research. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with academia. The clinical Phase II trials for glioblastoma are sponsored by the Swedish National Neuro-Oncology Group and, presently, involve a protocol for BNCT treatment of glioblastoma patients who have not received any therapy other than surgery. In this protocol, p-boronophenylalanine (BPA), administered as a 6-h intravenous infusion, is used as the boron delivery agent. As of January 2002, 17 patients were treated. The 6-h infusion of 900 mg BPA/kg body weight was shown to be safe and resulted in the average blood-boron concentration of 24 μg/g (range: 15-32 μg/g) at the time of irradiation (approximately 2-3 h post-infusion). Peak and average weighted radiation doses to the brain were in the ranges of 8.0-15.5 Gy(W) and 3.3-6.1 Gy(W), respectively. So far, no severe BNCT-related acute toxicities have been observed. Due to the short follow-up time, it is too early to evaluate the efficacy of these studies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
boronophenylalanine, glioblastoma multiforme, radiation therapy, boron neutron capture therapy, BNCT, clinical, trials
in
Journal of Neuro-Oncology
volume
62
issue
1
pages
10 pages
publisher
Springer
external identifiers
  • wos:000182070200013
  • scopus:0037847454
  • pmid:12749709
ISSN
1573-7373
DOI
10.1023/A:1023230801571
language
English
LU publication?
yes
id
fb645d75-bb90-4e5a-a4bb-b5c197a562e5 (old id 314888)
date added to LUP
2016-04-01 16:53:22
date last changed
2023-07-20 08:31:41
@article{fb645d75-bb90-4e5a-a4bb-b5c197a562e5,
  abstract     = {{<p>A boron neutron capture therapy (BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/moderator configurations. One of the resulting neutron beams has been optimized for clinical irradiations with a filter/moderator system that allows easy variation of the neutron spectrum from the thermal to the epithermal energy range. The other beam has been designed to produce a large uniform field of thermal neutrons for radio-biological research. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with academia. The clinical Phase II trials for glioblastoma are sponsored by the Swedish National Neuro-Oncology Group and, presently, involve a protocol for BNCT treatment of glioblastoma patients who have not received any therapy other than surgery. In this protocol, p-boronophenylalanine (BPA), administered as a 6-h intravenous infusion, is used as the boron delivery agent. As of January 2002, 17 patients were treated. The 6-h infusion of 900 mg BPA/kg body weight was shown to be safe and resulted in the average blood-boron concentration of 24 μg/g (range: 15-32 μg/g) at the time of irradiation (approximately 2-3 h post-infusion). Peak and average weighted radiation doses to the brain were in the ranges of 8.0-15.5 Gy(W) and 3.3-6.1 Gy(W), respectively. So far, no severe BNCT-related acute toxicities have been observed. Due to the short follow-up time, it is too early to evaluate the efficacy of these studies.</p>}},
  author       = {{Capala, J and Stenstam, BH and Skold, KS and Munck af Rosenschöld, Per and Giusti, V and Persson, C and Wallin, E and Brun, A and Franzen, L and Carlsson, JO and Salford, Leif and Ceberg, Crister and Persson, Bertil R and Pellettieri, L and Henriksson, R}},
  issn         = {{1573-7373}},
  keywords     = {{boronophenylalanine; glioblastoma multiforme; radiation therapy; boron neutron capture therapy; BNCT; clinical; trials}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{135--144}},
  publisher    = {{Springer}},
  series       = {{Journal of Neuro-Oncology}},
  title        = {{Boron neutron capture therapy for glioblastoma multiforme : Clinical studies in Sweden}},
  url          = {{http://dx.doi.org/10.1023/A:1023230801571}},
  doi          = {{10.1023/A:1023230801571}},
  volume       = {{62}},
  year         = {{2003}},
}