Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas
(2002) In Oncogene 21(26). p.4181-4190- Abstract
- The chromosomal translocation t(X;18)(p11.2;q11.2) is tightly linked to the tumorigenesis of synovial sarcoma. Through this translation the SYT gene on chromosome 18 is fused with a testis/cancer antigen gene on the X chromosome, generating either a SYT-SSX1, SYT-SSX2, or less often a SYT-SSX4 fusion gene. It has been anticipated that the individual synovial sarcoma carries only one of these variants, however, in this study we demonstrated that SYT-SSX1 and SYT-SSX2 coexist in a significant proportion of the cases. From 121 SYT-SSX positive primary tumors, co-expression of SYT-SSX1 and SYT-SSX2 was seen in 12 cases (10%), which were characterized in further detail both at the RNA, DNA and chromosomal level. In all 12 cases the SYT-SSX1 and... (More)
- The chromosomal translocation t(X;18)(p11.2;q11.2) is tightly linked to the tumorigenesis of synovial sarcoma. Through this translation the SYT gene on chromosome 18 is fused with a testis/cancer antigen gene on the X chromosome, generating either a SYT-SSX1, SYT-SSX2, or less often a SYT-SSX4 fusion gene. It has been anticipated that the individual synovial sarcoma carries only one of these variants, however, in this study we demonstrated that SYT-SSX1 and SYT-SSX2 coexist in a significant proportion of the cases. From 121 SYT-SSX positive primary tumors, co-expression of SYT-SSX1 and SYT-SSX2 was seen in 12 cases (10%), which were characterized in further detail both at the RNA, DNA and chromosomal level. In all 12 cases the SYT-SSX1 and SYT-SSX2 fusions resulted in identical SYT-SSX fusion transcripts. However, at the genomic level the translocations were different, and most likely occurred between variable intronic sites in the target genes. By interphase FISH analyses of 10 cases SYT-SSX2 translocations were found to be the most abundant in all but one of the cases, in which SYT-SSX1 was predominating. The findings reveal a new heterogenous feature of synovial sarcoma, accounting for approximately 10% of all cases, which may shed light on the molecular genetic mechanisms behind translocations in general, and on the etiology of synovial sarcoma in particular. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/335422
- author
- Yang, K ; Lui, WO ; Xie, YT ; Zhang, AJ ; Skytting, B ; Mandahl, Nils LU ; Larsson, C and Larsson, O
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- double fusion, synovial sarcoma, SYT-SSX, double translocation
- in
- Oncogene
- volume
- 21
- issue
- 26
- pages
- 4181 - 4190
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:12037676
- wos:000176186000014
- scopus:0037071884
- ISSN
- 1476-5594
- DOI
- 10.1038/sj.onc.1205569
- language
- English
- LU publication?
- yes
- id
- 08984e0c-8dd7-4085-99e1-56fef2be4121 (old id 335422)
- date added to LUP
- 2016-04-01 12:07:41
- date last changed
- 2022-03-13 05:39:24
@article{08984e0c-8dd7-4085-99e1-56fef2be4121, abstract = {{The chromosomal translocation t(X;18)(p11.2;q11.2) is tightly linked to the tumorigenesis of synovial sarcoma. Through this translation the SYT gene on chromosome 18 is fused with a testis/cancer antigen gene on the X chromosome, generating either a SYT-SSX1, SYT-SSX2, or less often a SYT-SSX4 fusion gene. It has been anticipated that the individual synovial sarcoma carries only one of these variants, however, in this study we demonstrated that SYT-SSX1 and SYT-SSX2 coexist in a significant proportion of the cases. From 121 SYT-SSX positive primary tumors, co-expression of SYT-SSX1 and SYT-SSX2 was seen in 12 cases (10%), which were characterized in further detail both at the RNA, DNA and chromosomal level. In all 12 cases the SYT-SSX1 and SYT-SSX2 fusions resulted in identical SYT-SSX fusion transcripts. However, at the genomic level the translocations were different, and most likely occurred between variable intronic sites in the target genes. By interphase FISH analyses of 10 cases SYT-SSX2 translocations were found to be the most abundant in all but one of the cases, in which SYT-SSX1 was predominating. The findings reveal a new heterogenous feature of synovial sarcoma, accounting for approximately 10% of all cases, which may shed light on the molecular genetic mechanisms behind translocations in general, and on the etiology of synovial sarcoma in particular.}}, author = {{Yang, K and Lui, WO and Xie, YT and Zhang, AJ and Skytting, B and Mandahl, Nils and Larsson, C and Larsson, O}}, issn = {{1476-5594}}, keywords = {{double fusion; synovial sarcoma; SYT-SSX; double translocation}}, language = {{eng}}, number = {{26}}, pages = {{4181--4190}}, publisher = {{Nature Publishing Group}}, series = {{Oncogene}}, title = {{Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas}}, url = {{http://dx.doi.org/10.1038/sj.onc.1205569}}, doi = {{10.1038/sj.onc.1205569}}, volume = {{21}}, year = {{2002}}, }