Association between CD8(+) T cell subsets and cardiovascular disease.
Kolbus, Daniel ; Ljungcrantz, Irena LU ; Andersson, Linda LU ; Hedblad, Bo LU ; Nordin Fredrikson, Gunilla LU ; Björkbacka, Harry LU
and Nilsson, Jan
(2013)
In Journal of Internal Medicine
274(1).
p.41-51
- Abstract
- OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. DESIGN: The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140°C, were thawed and the different CD8(+) T cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by... (More)
- OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. DESIGN: The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140°C, were thawed and the different CD8(+) T cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. RESULTS: Subjects with a high fraction of CD8(+) T cells were characterized by decreased cytokine release from activated leukocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8(+) T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8(+) CD25(+) T cells and the degree of carotid stenosis (r=0.11, P<0.01), and between the CD8(+) CD56(-) IFN-γ(+) T cell fraction and the degree of stenosis (r=-0.18, P<0.005). The association between CD8(+) CD56(-) IFN-γ(+) T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. CONCLUSION: The present study provides prospective clinical evidence for a role of CD8(+) T cells in cardiovascular disease and suggests the existence of CD8(+) T cell subsets with different pathological functions. © 2013 The Association for the Publication of the Journal of Internal Medicine. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3438206
- author
- Kolbus, Daniel
; Ljungcrantz, Irena
LU
; Andersson, Linda
LU
; Hedblad, Bo
LU
; Nordin Fredrikson, Gunilla
LU
; Björkbacka, Harry
LU
and Nilsson, Jan
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Internal Medicine
- volume
- 274
- issue
- 1
- pages
- 41 - 51
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000320279000003
- pmid:23356723
- scopus:84879109428
- pmid:23356723
- ISSN
- 1365-2796
- DOI
- 10.1111/joim.12038
- language
- English
- LU publication?
- yes
- id
- a973b387-55ea-4d3a-b656-076896143250 (old id 3438206)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23356723?dopt=Abstract
- date added to LUP
- 2016-04-01 10:53:37
- date last changed
- 2022-03-04 23:52:28
@article{a973b387-55ea-4d3a-b656-076896143250,
abstract = {{OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. DESIGN: The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140°C, were thawed and the different CD8(+) T cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. RESULTS: Subjects with a high fraction of CD8(+) T cells were characterized by decreased cytokine release from activated leukocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8(+) T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8(+) CD25(+) T cells and the degree of carotid stenosis (r=0.11, P<0.01), and between the CD8(+) CD56(-) IFN-γ(+) T cell fraction and the degree of stenosis (r=-0.18, P<0.005). The association between CD8(+) CD56(-) IFN-γ(+) T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. CONCLUSION: The present study provides prospective clinical evidence for a role of CD8(+) T cells in cardiovascular disease and suggests the existence of CD8(+) T cell subsets with different pathological functions. © 2013 The Association for the Publication of the Journal of Internal Medicine.}},
author = {{Kolbus, Daniel and Ljungcrantz, Irena and Andersson, Linda and Hedblad, Bo and Nordin Fredrikson, Gunilla and Björkbacka, Harry and Nilsson, Jan}},
issn = {{1365-2796}},
language = {{eng}},
number = {{1}},
pages = {{41--51}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Association between CD8(+) T cell subsets and cardiovascular disease.}},
url = {{http://dx.doi.org/10.1111/joim.12038}},
doi = {{10.1111/joim.12038}},
volume = {{274}},
year = {{2013}},
}