B cells.
Ollila, Juha and Vihinen, Mauno LU
(2005)
In International Journal of Biochemistry & Cell Biology
37(3).
p.518-523
- Abstract
- B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other processes including somatic hypermutation, gene conversion and class switching. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two Ig heavy chains, two Ig light chains and two heterodimers of Igalpha and Igbeta. To eliminate foreign antigens, B cells cooperate with other cells of the immune system including macrophages, dendritic cells and T cells. B cell... (More)
- B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other processes including somatic hypermutation, gene conversion and class switching. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two Ig heavy chains, two Ig light chains and two heterodimers of Igalpha and Igbeta. To eliminate foreign antigens, B cells cooperate with other cells of the immune system including macrophages, dendritic cells and T cells. B cell development is a tightly controlled process in which over 75% of the developing cells become apoptotic because of inappropriate immunoglobulin gene rearrangements or recognition of self antigens by Igs. Hence, the majority of B cell-associated disorders are caused by the incorrect function of genes/proteins involved in B cell development. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3635441
- author
- Ollila, Juha
and Vihinen, Mauno
LU
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- B-Cell: genetics, Antigen, Receptors, Immunoglobulins: deficiency, Immunoglobulin alpha-Chains: genetics, Immunoglobulin Light Chains: genetics, Immunoglobulin Heavy Chains: genetics, Immunoglobulin G: metabolism, Immunoglobulin G: genetics, B-Lymphocytes: immunology, B-Lymphocytes: metabolism, B-Cell: metabolism, T-Lymphocytes: immunology, VDJ Recombinases: genetics
- in
- International Journal of Biochemistry & Cell Biology
- volume
- 37
- issue
- 3
- pages
- 518 - 523
- publisher
- Elsevier
- external identifiers
-
- pmid:15618007
- scopus:11144301815
- pmid:15618007
- ISSN
- 1878-5875
- DOI
- 10.1016/j.biocel.2004.09.007
- language
- English
- LU publication?
- no
- id
- ba97b86c-7040-46f8-a321-b04b05f0ac86 (old id 3635441)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/15618007?dopt=Abstract
- date added to LUP
- 2016-04-04 09:22:06
- date last changed
- 2022-04-23 20:13:10
@article{ba97b86c-7040-46f8-a321-b04b05f0ac86,
abstract = {{B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other processes including somatic hypermutation, gene conversion and class switching. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two Ig heavy chains, two Ig light chains and two heterodimers of Igalpha and Igbeta. To eliminate foreign antigens, B cells cooperate with other cells of the immune system including macrophages, dendritic cells and T cells. B cell development is a tightly controlled process in which over 75% of the developing cells become apoptotic because of inappropriate immunoglobulin gene rearrangements or recognition of self antigens by Igs. Hence, the majority of B cell-associated disorders are caused by the incorrect function of genes/proteins involved in B cell development.}},
author = {{Ollila, Juha and Vihinen, Mauno}},
issn = {{1878-5875}},
keywords = {{B-Cell: genetics; Antigen; Receptors; Immunoglobulins: deficiency; Immunoglobulin alpha-Chains: genetics; Immunoglobulin Light Chains: genetics; Immunoglobulin Heavy Chains: genetics; Immunoglobulin G: metabolism; Immunoglobulin G: genetics; B-Lymphocytes: immunology; B-Lymphocytes: metabolism; B-Cell: metabolism; T-Lymphocytes: immunology; VDJ Recombinases: genetics}},
language = {{eng}},
number = {{3}},
pages = {{518--523}},
publisher = {{Elsevier}},
series = {{International Journal of Biochemistry & Cell Biology}},
title = {{B cells.}},
url = {{http://dx.doi.org/10.1016/j.biocel.2004.09.007}},
doi = {{10.1016/j.biocel.2004.09.007}},
volume = {{37}},
year = {{2005}},
}