Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice
(2016) In Blood 128(2). p.217-226- Abstract
Although it is well established that unique B-cell lineages develop through distinct regulatory mechanisms during embryonic development, much less is understood about the differences between embryonic and adult B-cell progenitor cells, likely to underpin the genetics and biology of infant and childhood PreB acute lymphoblastic leukemia (PreB-ALL), initiated by distinct leukemia-initiating translocations during embryonic development. Herein, we establish that a distinct subset of the earliest CD19+ B-cell progenitors emerging in the E13.5 mouse fetal liver express the colony-stimulating factor-1 receptor (CSF1R), previously thought to be expressed, and play a lineage-restricted role in development of myeloid lineages, and... (More)
Although it is well established that unique B-cell lineages develop through distinct regulatory mechanisms during embryonic development, much less is understood about the differences between embryonic and adult B-cell progenitor cells, likely to underpin the genetics and biology of infant and childhood PreB acute lymphoblastic leukemia (PreB-ALL), initiated by distinct leukemia-initiating translocations during embryonic development. Herein, we establish that a distinct subset of the earliest CD19+ B-cell progenitors emerging in the E13.5 mouse fetal liver express the colony-stimulating factor-1 receptor (CSF1R), previously thought to be expressed, and play a lineage-restricted role in development of myeloid lineages, and macrophages in particular. These early embryonic CSF1R+CD19+ ProB cells also express multiple other myeloid genes and, in line with this, possess residual myeloid as well as B-cell, but not T-cell lineage potential. Notably, these CSF1R+ myeloid-primed ProB cells are uniquely present in a narrow window of embryonic fetal liver hematopoiesis and do not persist in adult bone marrow. Moreover, analysis of CSF1R-deficient mice establishes a distinct role of CSF1R in fetal B-lymphopoiesis. CSF1R+ myeloid-primed embryonic ProB cells are relevant for infant and childhood PreB-ALLs, which frequently have a bi-phenotypic B-myeloid phenotype, and in which CSF1R-rearrangements have recently been reported.
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- author
- Zriwil, Alya LU ; Böiers, Charlotta LU ; Wittmann, Lilian LU ; Green, Joanna C A ; Woll, Petter S. ; Jacobsen, Sten Eirik W LU and Sitnicka, Ewa LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 128
- issue
- 2
- pages
- 10 pages
- publisher
- American Society of Hematology
- external identifiers
-
- scopus:84994016174
- pmid:27207794
- wos:000383830000013
- ISSN
- 0006-4971
- DOI
- 10.1182/blood-2016-01-693887
- language
- English
- LU publication?
- yes
- id
- 367b2eed-4d17-4f84-b221-2aae431751f2
- date added to LUP
- 2016-12-05 08:54:07
- date last changed
- 2024-05-03 15:12:45
@article{367b2eed-4d17-4f84-b221-2aae431751f2, abstract = {{<p>Although it is well established that unique B-cell lineages develop through distinct regulatory mechanisms during embryonic development, much less is understood about the differences between embryonic and adult B-cell progenitor cells, likely to underpin the genetics and biology of infant and childhood PreB acute lymphoblastic leukemia (PreB-ALL), initiated by distinct leukemia-initiating translocations during embryonic development. Herein, we establish that a distinct subset of the earliest CD19<sup>+</sup> B-cell progenitors emerging in the E13.5 mouse fetal liver express the colony-stimulating factor-1 receptor (CSF1R), previously thought to be expressed, and play a lineage-restricted role in development of myeloid lineages, and macrophages in particular. These early embryonic CSF1R<sup>+</sup>CD19<sup>+</sup> ProB cells also express multiple other myeloid genes and, in line with this, possess residual myeloid as well as B-cell, but not T-cell lineage potential. Notably, these CSF1R<sup>+</sup> myeloid-primed ProB cells are uniquely present in a narrow window of embryonic fetal liver hematopoiesis and do not persist in adult bone marrow. Moreover, analysis of CSF1R-deficient mice establishes a distinct role of CSF1R in fetal B-lymphopoiesis. CSF1R<sup>+</sup> myeloid-primed embryonic ProB cells are relevant for infant and childhood PreB-ALLs, which frequently have a bi-phenotypic B-myeloid phenotype, and in which CSF1R-rearrangements have recently been reported.</p>}}, author = {{Zriwil, Alya and Böiers, Charlotta and Wittmann, Lilian and Green, Joanna C A and Woll, Petter S. and Jacobsen, Sten Eirik W and Sitnicka, Ewa}}, issn = {{0006-4971}}, language = {{eng}}, number = {{2}}, pages = {{217--226}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice}}, url = {{http://dx.doi.org/10.1182/blood-2016-01-693887}}, doi = {{10.1182/blood-2016-01-693887}}, volume = {{128}}, year = {{2016}}, }