Identification of novel transcription factor-like gene from human intestinal cells
(2000) In Biochemical and Biophysical Research Communications 276(2). p.660-666- Abstract
- Intestinal crypt epithelial T84 cells form luminal structures and differentiate to intestinal enterocyte-like cells in response to IMR-90 fibroblast-secreted transforming growth factor-beta when grown within three-dimensional collagen gel. In search of TGF-beta regulated genes involved in this differentiation process, we isolated a TGF-beta downregulated cDNA, human homologue of rat apoptosis antagonising transcription factor that codes for a 560-amino-acid protein. Human AATF-mRNA was expressed at high levels in human brain, heart, thymus, kidney, and placenta while in skeletal muscle and colon the expression was lower. The gene was mapped to chromosome 17q11.2-q12. (C) 2000 Academic Press.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3851981
- author
- Lindfors, K ; Halttunen, T ; Huotari, P ; Nupponen, N ; Vihinen, Mauno LU ; Visakorpi, T ; Maki, M and Kainulainen, H
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- TGF-beta, differentiation, transcription factor, AATF
- in
- Biochemical and Biophysical Research Communications
- volume
- 276
- issue
- 2
- pages
- 660 - 666
- publisher
- Elsevier
- external identifiers
-
- wos:000089558600043
- scopus:0034710824
- ISSN
- 1090-2104
- DOI
- 10.1006/bbrc.2000.3480
- language
- English
- LU publication?
- no
- id
- a251c746-e9fc-4901-b191-971453e29818 (old id 3851981)
- date added to LUP
- 2016-04-01 15:39:23
- date last changed
- 2022-01-28 06:27:28
@article{a251c746-e9fc-4901-b191-971453e29818, abstract = {{Intestinal crypt epithelial T84 cells form luminal structures and differentiate to intestinal enterocyte-like cells in response to IMR-90 fibroblast-secreted transforming growth factor-beta when grown within three-dimensional collagen gel. In search of TGF-beta regulated genes involved in this differentiation process, we isolated a TGF-beta downregulated cDNA, human homologue of rat apoptosis antagonising transcription factor that codes for a 560-amino-acid protein. Human AATF-mRNA was expressed at high levels in human brain, heart, thymus, kidney, and placenta while in skeletal muscle and colon the expression was lower. The gene was mapped to chromosome 17q11.2-q12. (C) 2000 Academic Press.}}, author = {{Lindfors, K and Halttunen, T and Huotari, P and Nupponen, N and Vihinen, Mauno and Visakorpi, T and Maki, M and Kainulainen, H}}, issn = {{1090-2104}}, keywords = {{TGF-beta; differentiation; transcription factor; AATF}}, language = {{eng}}, number = {{2}}, pages = {{660--666}}, publisher = {{Elsevier}}, series = {{Biochemical and Biophysical Research Communications}}, title = {{Identification of novel transcription factor-like gene from human intestinal cells}}, url = {{http://dx.doi.org/10.1006/bbrc.2000.3480}}, doi = {{10.1006/bbrc.2000.3480}}, volume = {{276}}, year = {{2000}}, }