The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence
(2013) In International Journal of Cardiology 167(2). p.362-368- Abstract
- Background: Matrix metalloproteinase-8 (MMP-8) is involved in the breakdown of the extracellular matrix increasing the vulnerability of atherosclerotic lesions. We analysed the diagnostic value of serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in acute coronary syndrome (ACS) and their prognostic value in ACS recurrence. Methods: The population comprised 343 patients with ACS [including 108 unstable angina pectoris and 235 acute myocardial infarctions (AMI)] and 326 healthy controls. Additionally, 157 (45.8%) patients were resampled during the recovery. The ACS patients were followed up for 6 years. Results: MMP-8, TIMP-1, and their molar ratio distinguished the cases from the controls; C-statistic of the... (More)
- Background: Matrix metalloproteinase-8 (MMP-8) is involved in the breakdown of the extracellular matrix increasing the vulnerability of atherosclerotic lesions. We analysed the diagnostic value of serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in acute coronary syndrome (ACS) and their prognostic value in ACS recurrence. Methods: The population comprised 343 patients with ACS [including 108 unstable angina pectoris and 235 acute myocardial infarctions (AMI)] and 326 healthy controls. Additionally, 157 (45.8%) patients were resampled during the recovery. The ACS patients were followed up for 6 years. Results: MMP-8, TIMP-1, and their molar ratio distinguished the cases from the controls; C-statistic of the multivariate model (95% CI, p-value) including the MMP-8/TIMP-1 ratio regarding its discriminating ability for AMI was 0.922 (0.893-0.950, p < 0.001). After the acute phase of ACS, median MMP-8 and TIMP-1 concentrations decreased (p < 0.001) by 34.5 and 28.7%, respectively, but ended up on a different level than those found in the controls. In the follow-up, acute phase and recovery period TIMP-1 concentrations associated with cardiovascular death with hazard ratios 4.31 (2.00-9.26, p < 0.001) and 4.69 (1.10-20.01, p = 0.037), respectively. Conclusions: The increase of serum MMP-8 and TIMP-1 concentrations may reflect plaque instability and tissue damage. TIMP-1 concentrations are associated with poor outcome in patients with ACS. The findings may have practical implications in both diagnostics and therapeutics. (c) 2011 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3979518
- author
- Pussinen, Pirkko J. ; Sarna, Seppo ; Puolakkainen, Mirja ; Öhlin, Hans LU ; Sorsa, Timo and Pesonen, Erkki LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute coronary syndrome, Acute myocardial infarction, Unstable angina, pectoris, Inflammation, Matrix metalloproteinase-8, Tissue inhibitor of, metalloproteinases-1
- in
- International Journal of Cardiology
- volume
- 167
- issue
- 2
- pages
- 362 - 368
- publisher
- Elsevier
- external identifiers
-
- wos:000320768800020
- scopus:84879069722
- pmid:22257687
- ISSN
- 0167-5273
- DOI
- 10.1016/j.ijcard.2011.12.095
- language
- English
- LU publication?
- yes
- id
- 3b357693-0fff-4275-a57e-f0b06690eedc (old id 3979518)
- date added to LUP
- 2016-04-01 10:32:46
- date last changed
- 2022-04-12 07:23:50
@article{3b357693-0fff-4275-a57e-f0b06690eedc, abstract = {{Background: Matrix metalloproteinase-8 (MMP-8) is involved in the breakdown of the extracellular matrix increasing the vulnerability of atherosclerotic lesions. We analysed the diagnostic value of serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in acute coronary syndrome (ACS) and their prognostic value in ACS recurrence. Methods: The population comprised 343 patients with ACS [including 108 unstable angina pectoris and 235 acute myocardial infarctions (AMI)] and 326 healthy controls. Additionally, 157 (45.8%) patients were resampled during the recovery. The ACS patients were followed up for 6 years. Results: MMP-8, TIMP-1, and their molar ratio distinguished the cases from the controls; C-statistic of the multivariate model (95% CI, p-value) including the MMP-8/TIMP-1 ratio regarding its discriminating ability for AMI was 0.922 (0.893-0.950, p < 0.001). After the acute phase of ACS, median MMP-8 and TIMP-1 concentrations decreased (p < 0.001) by 34.5 and 28.7%, respectively, but ended up on a different level than those found in the controls. In the follow-up, acute phase and recovery period TIMP-1 concentrations associated with cardiovascular death with hazard ratios 4.31 (2.00-9.26, p < 0.001) and 4.69 (1.10-20.01, p = 0.037), respectively. Conclusions: The increase of serum MMP-8 and TIMP-1 concentrations may reflect plaque instability and tissue damage. TIMP-1 concentrations are associated with poor outcome in patients with ACS. The findings may have practical implications in both diagnostics and therapeutics. (c) 2011 Elsevier Ireland Ltd. All rights reserved.}}, author = {{Pussinen, Pirkko J. and Sarna, Seppo and Puolakkainen, Mirja and Öhlin, Hans and Sorsa, Timo and Pesonen, Erkki}}, issn = {{0167-5273}}, keywords = {{Acute coronary syndrome; Acute myocardial infarction; Unstable angina; pectoris; Inflammation; Matrix metalloproteinase-8; Tissue inhibitor of; metalloproteinases-1}}, language = {{eng}}, number = {{2}}, pages = {{362--368}}, publisher = {{Elsevier}}, series = {{International Journal of Cardiology}}, title = {{The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence}}, url = {{https://lup.lub.lu.se/search/files/1934019/4178498.pdf}}, doi = {{10.1016/j.ijcard.2011.12.095}}, volume = {{167}}, year = {{2013}}, }