Linking bronchopulmonary dysplasia to adult chronic lung diseases : role of WNT signaling
(2016) In Molecular and cellular pediatrics 3. p.1-13- Abstract
Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung... (More)
Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.
(Less)
- author
- Ota, Chiharu ; Baarsma, Hoeke A. ; Wagner, Darcy E LU ; Hilgendorff, Anne and Königshoff, Melanie
- publishing date
- 2016-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Review, Journal Article
- in
- Molecular and cellular pediatrics
- volume
- 3
- article number
- 34
- pages
- 1 - 13
- publisher
- Springer
- external identifiers
-
- pmid:27718180
- scopus:85011348658
- ISSN
- 2194-7791
- DOI
- 10.1186/s40348-016-0062-6
- language
- English
- LU publication?
- no
- id
- 3ce680e2-b2c0-473a-bf5c-76033e8336bb
- date added to LUP
- 2017-08-15 15:19:18
- date last changed
- 2024-09-21 08:19:10
@article{3ce680e2-b2c0-473a-bf5c-76033e8336bb, abstract = {{<p>Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.</p>}}, author = {{Ota, Chiharu and Baarsma, Hoeke A. and Wagner, Darcy E and Hilgendorff, Anne and Königshoff, Melanie}}, issn = {{2194-7791}}, keywords = {{Review; Journal Article}}, language = {{eng}}, pages = {{1--13}}, publisher = {{Springer}}, series = {{Molecular and cellular pediatrics}}, title = {{Linking bronchopulmonary dysplasia to adult chronic lung diseases : role of WNT signaling}}, url = {{http://dx.doi.org/10.1186/s40348-016-0062-6}}, doi = {{10.1186/s40348-016-0062-6}}, volume = {{3}}, year = {{2016}}, }