Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia
(2013) In Reviews in the Neurosciences 24(4). p.415-429- Abstract
- A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the... (More)
- A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4033751
- author
- Richter, Ulrike LU ; Halje, Pär LU and Petersson, Per LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- basal ganglia, dopamine, motor cortex, neuronal circuits, oscillations, Parkinson's disease
- in
- Reviews in the Neurosciences
- volume
- 24
- issue
- 4
- pages
- 415 - 429
- publisher
- Freund Publishing House Ltd
- external identifiers
-
- wos:000322972500006
- scopus:84888180105
- ISSN
- 0334-1763
- DOI
- 10.1515/revneuro-2013-0018
- language
- English
- LU publication?
- yes
- id
- 3abe70b7-24f9-48d5-bf65-65dbc25d701a (old id 4033751)
- date added to LUP
- 2016-04-01 15:03:49
- date last changed
- 2022-03-22 03:19:56
@article{3abe70b7-24f9-48d5-bf65-65dbc25d701a,
abstract = {{A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies.}},
author = {{Richter, Ulrike and Halje, Pär and Petersson, Per}},
issn = {{0334-1763}},
keywords = {{basal ganglia; dopamine; motor cortex; neuronal circuits; oscillations; Parkinson's disease}},
language = {{eng}},
number = {{4}},
pages = {{415--429}},
publisher = {{Freund Publishing House Ltd}},
series = {{Reviews in the Neurosciences}},
title = {{Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia}},
url = {{https://lup.lub.lu.se/search/files/4321500/4350249.pdf}},
doi = {{10.1515/revneuro-2013-0018}},
volume = {{24}},
year = {{2013}},
}