Drug effect evaluation during permanent atrial fibrillation using an AV-node model
(2013) 2013 40th Computing in Cardiology Conference, CinC 2013 40. p.1243-1246- Abstract
The purpose of the present study is to evaluate the effect of rate control drugs on the AV node characteristics during atrial fibrillation (AF) using a model-based approach. A statistical model of the AV nodal function is employed, defined by parameters which characterize the arrival rate of atrial impulses, the refractoriness of the fast and the slow AV-nodal pathway and the probability of atrial impulse to pass through either of the two pathways. The RATAF (RATe control in Atrial Fibrillation) study database consists of recordings from 60 patients with permanent AF at baseline and on treatment with metoprolol, verapamil, diltiazem and carvedilol, respectively. The resulting model parameter estimates indicate that the refractory period... (More)
The purpose of the present study is to evaluate the effect of rate control drugs on the AV node characteristics during atrial fibrillation (AF) using a model-based approach. A statistical model of the AV nodal function is employed, defined by parameters which characterize the arrival rate of atrial impulses, the refractoriness of the fast and the slow AV-nodal pathway and the probability of atrial impulse to pass through either of the two pathways. The RATAF (RATe control in Atrial Fibrillation) study database consists of recordings from 60 patients with permanent AF at baseline and on treatment with metoprolol, verapamil, diltiazem and carvedilol, respectively. The resulting model parameter estimates indicate that the refractory period of the slow pathway as well as that of the fast pathway increased significantly during treatment with all four drugs. The results suggest that the proposed AV-node model can be used for non-invasive evaluation of the effect of rate control drugs.
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- author
- Sandberg, Frida LU ; Corino, Valentina D A ; Ulimoen, Sara Reinvik ; Enger, Steve ; Tveit, Arnljot ; Mainardi, Luca T. ; Platonov, Pyotr LU and Sornmo, Leif LU
- organization
- publishing date
- 2013
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Computing in Cardiology 2013, CinC 2013
- volume
- 40
- article number
- 6713609
- pages
- 4 pages
- conference name
- 2013 40th Computing in Cardiology Conference, CinC 2013
- conference location
- Zaragoza, Spain
- conference dates
- 2013-09-22 - 2013-09-25
- external identifiers
-
- scopus:84894202923
- ISBN
- 9781479908844
- language
- English
- LU publication?
- yes
- id
- 4112c2ac-e98d-4efa-a6b0-b9813c130f10
- alternative location
- http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=6713609
- date added to LUP
- 2017-08-09 15:17:35
- date last changed
- 2022-01-30 21:58:54
@inproceedings{4112c2ac-e98d-4efa-a6b0-b9813c130f10, abstract = {{<p>The purpose of the present study is to evaluate the effect of rate control drugs on the AV node characteristics during atrial fibrillation (AF) using a model-based approach. A statistical model of the AV nodal function is employed, defined by parameters which characterize the arrival rate of atrial impulses, the refractoriness of the fast and the slow AV-nodal pathway and the probability of atrial impulse to pass through either of the two pathways. The RATAF (RATe control in Atrial Fibrillation) study database consists of recordings from 60 patients with permanent AF at baseline and on treatment with metoprolol, verapamil, diltiazem and carvedilol, respectively. The resulting model parameter estimates indicate that the refractory period of the slow pathway as well as that of the fast pathway increased significantly during treatment with all four drugs. The results suggest that the proposed AV-node model can be used for non-invasive evaluation of the effect of rate control drugs.</p>}}, author = {{Sandberg, Frida and Corino, Valentina D A and Ulimoen, Sara Reinvik and Enger, Steve and Tveit, Arnljot and Mainardi, Luca T. and Platonov, Pyotr and Sornmo, Leif}}, booktitle = {{Computing in Cardiology 2013, CinC 2013}}, isbn = {{9781479908844}}, language = {{eng}}, pages = {{1243--1246}}, title = {{Drug effect evaluation during permanent atrial fibrillation using an AV-node model}}, url = {{http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=6713609}}, volume = {{40}}, year = {{2013}}, }