Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.
(2014) In Nature Communications 5(Jan 20).- Abstract
- The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling.... (More)
- The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that (89)Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4291013
- author
- Thorek, Daniel L J ; Ulmert, David LU ; Diop, Ndeye-Fatou M ; Lupu, Mihaela E ; Doran, Michael G ; Huang, Ruimin ; Abou, Diane S ; Larson, Steven M and Grimm, Jan
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 5
- issue
- Jan 20
- article number
- 3097
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:24445347
- wos:000331084400006
- scopus:84892861543
- pmid:24445347
- ISSN
- 2041-1723
- DOI
- 10.1038/ncomms4097
- language
- English
- LU publication?
- yes
- id
- b8505917-aee0-4471-81f9-1d35355b91c5 (old id 4291013)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24445347?dopt=Abstract
- date added to LUP
- 2016-04-01 13:23:08
- date last changed
- 2022-05-19 19:06:08
@article{b8505917-aee0-4471-81f9-1d35355b91c5, abstract = {{The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that (89)Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging.}}, author = {{Thorek, Daniel L J and Ulmert, David and Diop, Ndeye-Fatou M and Lupu, Mihaela E and Doran, Michael G and Huang, Ruimin and Abou, Diane S and Larson, Steven M and Grimm, Jan}}, issn = {{2041-1723}}, language = {{eng}}, number = {{Jan 20}}, publisher = {{Nature Publishing Group}}, series = {{Nature Communications}}, title = {{Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.}}, url = {{http://dx.doi.org/10.1038/ncomms4097}}, doi = {{10.1038/ncomms4097}}, volume = {{5}}, year = {{2014}}, }