Early Activation of Pulmonary TGF- β 1/Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury.
(2014) In Mediators of Inflammation 2014(Feb 12).- Abstract
- Acute lung injury is caused by many factors including acute pancreatitis. There is no specific therapy directed at underlying pathophysiological mechanisms for acute lung injury. Transforming growth factor- β (TGF- β ) is involved in the resolution of lung injury in later phases of the disease. Some evidence exists demonstrating that TGF- β not only is involved in the late stages, but also contributes to lung injury early on in the progress of the disease. Acute pancreatitis was induced using ductal ligation in mice. TGF- β 1, 2, and 3, T β RII, ALK-5, Smad2, 3, 4, and 7, and P-Smad2 expression in the lungs were analyzed at 9 and 24 h. We demonstrate that TGF- β 1 levels in the lungs of mice with acute pancreatitis increase as early as 9 h... (More)
- Acute lung injury is caused by many factors including acute pancreatitis. There is no specific therapy directed at underlying pathophysiological mechanisms for acute lung injury. Transforming growth factor- β (TGF- β ) is involved in the resolution of lung injury in later phases of the disease. Some evidence exists demonstrating that TGF- β not only is involved in the late stages, but also contributes to lung injury early on in the progress of the disease. Acute pancreatitis was induced using ductal ligation in mice. TGF- β 1, 2, and 3, T β RII, ALK-5, Smad2, 3, 4, and 7, and P-Smad2 expression in the lungs were analyzed at 9 and 24 h. We demonstrate that TGF- β 1 levels in the lungs of mice with acute pancreatitis increase as early as 9 h after induction. We observed an increased expression of ALK-5 in acute pancreatitis at both 9 and 24 h. Inhibitory Smad7 expression was transiently increased at 9 h in acute pancreatitis, but reduced later at 24 h, with a concomitant increased nuclear translocation of phosphorylated Smad2. Our findings demonstrate activation of TGF- β signaling in the lungs as early as 24 h after acute pancreatitis, suggesting that TGF- β may represent a potential therapeutic candidate in acute pancreatitis-induced acute lung injury. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4431356
- author
- Akbarshahi, Hamid LU ; Sam, Asha LU ; Chen, Chaolei LU ; Rosendahl, Ann LU and Andersson, Roland LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Mediators of Inflammation
- volume
- 2014
- issue
- Feb 12
- article number
- 148029
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:24688224
- wos:000331766300001
- scopus:84896383000
- pmid:24688224
- ISSN
- 0962-9351
- DOI
- 10.1155/2014/148029
- language
- English
- LU publication?
- yes
- id
- 9430476a-bfc9-4efb-8e3a-4bb9bd07a81e (old id 4431356)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24688224?dopt=Abstract
- date added to LUP
- 2016-04-01 09:49:30
- date last changed
- 2022-01-25 17:01:31
@article{9430476a-bfc9-4efb-8e3a-4bb9bd07a81e,
abstract = {{Acute lung injury is caused by many factors including acute pancreatitis. There is no specific therapy directed at underlying pathophysiological mechanisms for acute lung injury. Transforming growth factor- β (TGF- β ) is involved in the resolution of lung injury in later phases of the disease. Some evidence exists demonstrating that TGF- β not only is involved in the late stages, but also contributes to lung injury early on in the progress of the disease. Acute pancreatitis was induced using ductal ligation in mice. TGF- β 1, 2, and 3, T β RII, ALK-5, Smad2, 3, 4, and 7, and P-Smad2 expression in the lungs were analyzed at 9 and 24 h. We demonstrate that TGF- β 1 levels in the lungs of mice with acute pancreatitis increase as early as 9 h after induction. We observed an increased expression of ALK-5 in acute pancreatitis at both 9 and 24 h. Inhibitory Smad7 expression was transiently increased at 9 h in acute pancreatitis, but reduced later at 24 h, with a concomitant increased nuclear translocation of phosphorylated Smad2. Our findings demonstrate activation of TGF- β signaling in the lungs as early as 24 h after acute pancreatitis, suggesting that TGF- β may represent a potential therapeutic candidate in acute pancreatitis-induced acute lung injury.}},
author = {{Akbarshahi, Hamid and Sam, Asha and Chen, Chaolei and Rosendahl, Ann and Andersson, Roland}},
issn = {{0962-9351}},
language = {{eng}},
number = {{Feb 12}},
publisher = {{Hindawi Limited}},
series = {{Mediators of Inflammation}},
title = {{Early Activation of Pulmonary TGF- β 1/Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury.}},
url = {{https://lup.lub.lu.se/search/files/1288109/4732398}},
doi = {{10.1155/2014/148029}},
volume = {{2014}},
year = {{2014}},
}