Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy
(2014) In BioMed Research International 2014.- Abstract
- Background. Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy. Methods. We design a prospective longitudinal study (n = 30) with patients with persistent cow's milk proteins (CMP) allergy. After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th-1, Th-2, T-reg, and Th-17 cytokines were also monitored. Results. Baseline levels of PDGF and VEGF... (More)
- Background. Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy. Methods. We design a prospective longitudinal study (n = 30) with patients with persistent cow's milk proteins (CMP) allergy. After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th-1, Th-2, T-reg, and Th-17 cytokines were also monitored. Results. Baseline levels of PDGF and VEGF in the CMP allergic patients (1170 pg/mL and 253 pg/mL) were different compared to those nonallergic CMP control subjects (501 pg/mL and 108 pg/mL). Both PDGF and VEGF were significantly downregulated (P < 0.05) 6 months after completion of the CMP desensitization process and remained significantly decreased 12 months later. Conclusion. The present study shows a significant increase of PDGF and VEGF in anaphylaxis suffering children compared to a control group. Interestingly, both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4548046
- author
- Poza-Guedes, Paloma ; Barrios, Yvelise ; Fuentes, Victoria ; Franco, Andres ; Sanchez-Machin, Inmaculada ; Alonso, Elena ; Gonzalez Perez, Ruperto ; Infante, Sonsoles ; Zapatero, Lydia and Matheu, Victor LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BioMed Research International
- volume
- 2014
- article number
- 372567
- publisher
- Hindawi Limited
- external identifiers
-
- wos:000337425800001
- pmid:24995287
- scopus:84903625322
- pmid:24995287
- ISSN
- 2314-6133
- DOI
- 10.1155/2014/372567
- language
- English
- LU publication?
- yes
- id
- 206dc342-e4fd-46c2-b592-2a58b79d0e10 (old id 4548046)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24995287?dopt=Abstract
- date added to LUP
- 2016-04-01 10:35:40
- date last changed
- 2022-01-26 00:45:08
@article{206dc342-e4fd-46c2-b592-2a58b79d0e10, abstract = {{Background. Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy. Methods. We design a prospective longitudinal study (n = 30) with patients with persistent cow's milk proteins (CMP) allergy. After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th-1, Th-2, T-reg, and Th-17 cytokines were also monitored. Results. Baseline levels of PDGF and VEGF in the CMP allergic patients (1170 pg/mL and 253 pg/mL) were different compared to those nonallergic CMP control subjects (501 pg/mL and 108 pg/mL). Both PDGF and VEGF were significantly downregulated (P < 0.05) 6 months after completion of the CMP desensitization process and remained significantly decreased 12 months later. Conclusion. The present study shows a significant increase of PDGF and VEGF in anaphylaxis suffering children compared to a control group. Interestingly, both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization.}}, author = {{Poza-Guedes, Paloma and Barrios, Yvelise and Fuentes, Victoria and Franco, Andres and Sanchez-Machin, Inmaculada and Alonso, Elena and Gonzalez Perez, Ruperto and Infante, Sonsoles and Zapatero, Lydia and Matheu, Victor}}, issn = {{2314-6133}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{BioMed Research International}}, title = {{Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy}}, url = {{http://dx.doi.org/10.1155/2014/372567}}, doi = {{10.1155/2014/372567}}, volume = {{2014}}, year = {{2014}}, }