Factors That Predict Remission of Infant Atopic Dermatitis: A Systematic Review.
(2015) In Acta Dermato-Venereologica 95(4). p.389-394- Abstract
- The individual prognosis of infants with atopic dermatitis (AD) is important for parents, healthcare professionals, and society. The aim of this study was to investigate predictors for remission of infant AD until school age. A systematic review was carried out of clinical and epidemiological studies investigating the effect of filaggrin gene (FLG) loss-of-function mutations, sex, exposure to pets, topical anti-inflammatory treatment, disease severity, and atopic sensitization during infancy on complete remission of infant-onset AD until 6-7 years of age. Systematic electronic searches until September 2013, data abstraction, and study quality assessment (Newcastle-Ottawa Scale) were performed. From 3316 abstracts identified, 2 studies of... (More)
- The individual prognosis of infants with atopic dermatitis (AD) is important for parents, healthcare professionals, and society. The aim of this study was to investigate predictors for remission of infant AD until school age. A systematic review was carried out of clinical and epidemiological studies investigating the effect of filaggrin gene (FLG) loss-of-function mutations, sex, exposure to pets, topical anti-inflammatory treatment, disease severity, and atopic sensitization during infancy on complete remission of infant-onset AD until 6-7 years of age. Systematic electronic searches until September 2013, data abstraction, and study quality assessment (Newcastle-Ottawa Scale) were performed. From 3316 abstracts identified, 2 studies of good study quality were included. Parental allergies and sex did not significantly affect remission. For non-remission of AD, the included articles reported an association with any atopic sensitization at 2 years old (adjusted odds ratio [aOR] 2.76; 95% confidence interval (CI) 1.29-5.91), frequent scratching with early AD (aOR 5.86; 95% CI 3.04-11.29), severity score at 2 years old (aOR 1.10; 95% CI 1.07-1.14), and exposure to pets (cat OR 2.33; 95% CI 0.85-6.38). It is largely unknown which factors predict remission of infant AD. This is a highly relevant research gap that hinders patient information on the prognosis of infant-onset AD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4614820
- author
- von Kobyletzki, Laura LU ; Svensson, Åke LU ; Apfelbacher, Christian and Schmitt, Jochen
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Dermato-Venereologica
- volume
- 95
- issue
- 4
- pages
- 389 - 394
- publisher
- Medical Journals Limited
- external identifiers
-
- pmid:25117201
- wos:000352751200002
- scopus:84924985136
- pmid:25117201
- ISSN
- 1651-2057
- DOI
- 10.2340/00015555-1941
- language
- English
- LU publication?
- yes
- id
- 0fcd82f9-0bca-4f57-be88-cd0ef11366a7 (old id 4614820)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25117201?dopt=Abstract
- date added to LUP
- 2016-04-01 10:18:14
- date last changed
- 2022-03-12 04:33:09
@article{0fcd82f9-0bca-4f57-be88-cd0ef11366a7,
abstract = {{The individual prognosis of infants with atopic dermatitis (AD) is important for parents, healthcare professionals, and society. The aim of this study was to investigate predictors for remission of infant AD until school age. A systematic review was carried out of clinical and epidemiological studies investigating the effect of filaggrin gene (FLG) loss-of-function mutations, sex, exposure to pets, topical anti-inflammatory treatment, disease severity, and atopic sensitization during infancy on complete remission of infant-onset AD until 6-7 years of age. Systematic electronic searches until September 2013, data abstraction, and study quality assessment (Newcastle-Ottawa Scale) were performed. From 3316 abstracts identified, 2 studies of good study quality were included. Parental allergies and sex did not significantly affect remission. For non-remission of AD, the included articles reported an association with any atopic sensitization at 2 years old (adjusted odds ratio [aOR] 2.76; 95% confidence interval (CI) 1.29-5.91), frequent scratching with early AD (aOR 5.86; 95% CI 3.04-11.29), severity score at 2 years old (aOR 1.10; 95% CI 1.07-1.14), and exposure to pets (cat OR 2.33; 95% CI 0.85-6.38). It is largely unknown which factors predict remission of infant AD. This is a highly relevant research gap that hinders patient information on the prognosis of infant-onset AD.}},
author = {{von Kobyletzki, Laura and Svensson, Åke and Apfelbacher, Christian and Schmitt, Jochen}},
issn = {{1651-2057}},
language = {{eng}},
number = {{4}},
pages = {{389--394}},
publisher = {{Medical Journals Limited}},
series = {{Acta Dermato-Venereologica}},
title = {{Factors That Predict Remission of Infant Atopic Dermatitis: A Systematic Review.}},
url = {{https://lup.lub.lu.se/search/files/1731139/8310817.pdf}},
doi = {{10.2340/00015555-1941}},
volume = {{95}},
year = {{2015}},
}