Immune checkpoint therapy for pancreatic cancer
Johansson, Henrik ; Andersson, Roland LU ; Bauden, Monika LU
; Hammes, Sarah
; Holdenrieder, Stefan
and Ansari, Daniel
LU
(2016)
In World Journal of Gastroenterology
22(43).
p.9457-9476
- Abstract
Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic... (More)
Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic cancer. PubMed, ClinicalTrials.gov and American Society of Clinical Oncology's meeting abstracts were systematically searched for relevant clinical studies. Four articles, five abstracts and 25 clinical trials were identified and analyzed in detail.
(Less)
- author
- Johansson, Henrik
; Andersson, Roland
LU
; Bauden, Monika
LU
; Hammes, Sarah
; Holdenrieder, Stefan
and Ansari, Daniel
LU
- organization
- publishing date
- 2016-11-21
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Clinical trials, Immune checkpoint inhibitors, Pancreatic cancer
- in
- World Journal of Gastroenterology
- volume
- 22
- issue
- 43
- pages
- 20 pages
- publisher
- WJG Press
- external identifiers
-
- pmid:27920468
- wos:000389203400002
- scopus:84995904505
- ISSN
- 1007-9327
- DOI
- 10.3748/wjg.v22.i43.9457
- language
- English
- LU publication?
- yes
- id
- 481b8184-835c-4182-8bfb-6a91b11aa92a
- date added to LUP
- 2016-12-02 14:14:17
- date last changed
- 2024-04-05 11:36:43
@article{481b8184-835c-4182-8bfb-6a91b11aa92a,
abstract = {{<p>Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic cancer. PubMed, ClinicalTrials.gov and American Society of Clinical Oncology's meeting abstracts were systematically searched for relevant clinical studies. Four articles, five abstracts and 25 clinical trials were identified and analyzed in detail.</p>}},
author = {{Johansson, Henrik and Andersson, Roland and Bauden, Monika and Hammes, Sarah and Holdenrieder, Stefan and Ansari, Daniel}},
issn = {{1007-9327}},
keywords = {{Clinical trials; Immune checkpoint inhibitors; Pancreatic cancer}},
language = {{eng}},
month = {{11}},
number = {{43}},
pages = {{9457--9476}},
publisher = {{WJG Press}},
series = {{World Journal of Gastroenterology}},
title = {{Immune checkpoint therapy for pancreatic cancer}},
url = {{http://dx.doi.org/10.3748/wjg.v22.i43.9457}},
doi = {{10.3748/wjg.v22.i43.9457}},
volume = {{22}},
year = {{2016}},
}