Optimization of disintegration time and crushing strength of a tablet formulation
Lindberg, N.-O. ; Jönsson, C. and Holmquist, Björn LU
(1985)
In Drug Development and Industrial Pharmacy
11(4).
p.931-944
- Abstract
- In an experiment with a factorial design, the following aspects were scrutinized: the impact on disintegration time and crushing strength caused by the loss-on-drying of the granulation; the granule-size distribution; the lubricant concentration; the compression force; and the pre-compression. Both with regard to disintegration time and crushing strength, these factors were found to have a significant influence: the loss-on-drying of the granulation; the fraction less than 0.150 mm; the concentration of magnesium stearate; and the compression force. A reduction of the tablet disintegration time was obtained by means of an increase of the granulation moisture; by an increase of the fine fraction; or by a reduction of the lubricant... (More)
- In an experiment with a factorial design, the following aspects were scrutinized: the impact on disintegration time and crushing strength caused by the loss-on-drying of the granulation; the granule-size distribution; the lubricant concentration; the compression force; and the pre-compression. Both with regard to disintegration time and crushing strength, these factors were found to have a significant influence: the loss-on-drying of the granulation; the fraction less than 0.150 mm; the concentration of magnesium stearate; and the compression force. A reduction of the tablet disintegration time was obtained by means of an increase of the granulation moisture; by an increase of the fine fraction; or by a reduction of the lubricant concentration or the compression force. The tablet crushing strength was increased by reducing the deviation of the granulation loss-on-drying from approximately 4.6 %; by a reduction of the fine fraction; by decreasing the lubricant concentration; or by increasing the compression force. The fraction larger than 0.300 mm had no significant influence; nor did the pre-compression. Further, there were no significant interactions.
By means of superimposing contour plots of disintegration time and crushing strength, a region was obtained where the requirements of disintegration time and crushing strength could be satisfied by controlling the processing variables. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4897268
- author
- Lindberg, N.-O.
; Jönsson, C.
and Holmquist, Björn
LU
- organization
- publishing date
- 1985
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Development and Industrial Pharmacy
- volume
- 11
- issue
- 4
- pages
- 931 - 944
- publisher
- Marcel Dekker
- external identifiers
-
- scopus:0021888210
- ISSN
- 0363-9045
- DOI
- 10.3109/03639048509057467
- language
- English
- LU publication?
- yes
- id
- df0364b6-c0c2-4e0a-ab94-bc303df65612 (old id 4897268)
- date added to LUP
- 2016-04-01 12:35:37
- date last changed
- 2021-01-03 03:18:01
@article{df0364b6-c0c2-4e0a-ab94-bc303df65612,
abstract = {{In an experiment with a factorial design, the following aspects were scrutinized: the impact on disintegration time and crushing strength caused by the loss-on-drying of the granulation; the granule-size distribution; the lubricant concentration; the compression force; and the pre-compression. Both with regard to disintegration time and crushing strength, these factors were found to have a significant influence: the loss-on-drying of the granulation; the fraction less than 0.150 mm; the concentration of magnesium stearate; and the compression force. A reduction of the tablet disintegration time was obtained by means of an increase of the granulation moisture; by an increase of the fine fraction; or by a reduction of the lubricant concentration or the compression force. The tablet crushing strength was increased by reducing the deviation of the granulation loss-on-drying from approximately 4.6 %; by a reduction of the fine fraction; by decreasing the lubricant concentration; or by increasing the compression force. The fraction larger than 0.300 mm had no significant influence; nor did the pre-compression. Further, there were no significant interactions.<br/><br>
<br/><br>
By means of superimposing contour plots of disintegration time and crushing strength, a region was obtained where the requirements of disintegration time and crushing strength could be satisfied by controlling the processing variables.}},
author = {{Lindberg, N.-O. and Jönsson, C. and Holmquist, Björn}},
issn = {{0363-9045}},
language = {{eng}},
number = {{4}},
pages = {{931--944}},
publisher = {{Marcel Dekker}},
series = {{Drug Development and Industrial Pharmacy}},
title = {{Optimization of disintegration time and crushing strength of a tablet formulation}},
url = {{http://dx.doi.org/10.3109/03639048509057467}},
doi = {{10.3109/03639048509057467}},
volume = {{11}},
year = {{1985}},
}