Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke
(2017) In Stroke 48(10). p.2686-2692- Abstract
BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.
METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A total of 4706 subjects with no history of stroke were included (40% men; mean age, 57.5 years). Carotid plaque was determined by B-mode ultrasound of the right carotid artery. Incidence of stroke was followed up during a mean period of 16.5 years in relation to plasma ECP levels.
RESULTS: Subjects in the third tertile (versus first... (More)
BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.
METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A total of 4706 subjects with no history of stroke were included (40% men; mean age, 57.5 years). Carotid plaque was determined by B-mode ultrasound of the right carotid artery. Incidence of stroke was followed up during a mean period of 16.5 years in relation to plasma ECP levels.
RESULTS: Subjects in the third tertile (versus first tertile) of ECP tended to have higher prevalence of carotid plaque (odds ratio: 1.18; 95% confidence interval: 1.003-1.39; P=0.044 after multivariate adjustments). A total of 258 subjects were diagnosed with ischemic stroke (IS) during follow-up. ECP was associated with increased incidence of IS after risk factor adjustment (hazard ratio, 1.57; 95% confidence interval: 1.13-2.18; for third versus first tertile; P=0.007). High ECP was associated with increased risk of IS in subjects with carotid plaque. The risk factor-adjusted hazard ratio for IS was 1.86 (95% confidence interval: 1.32-2.63) in subjects with carotid plaque and ECP in the top tertile, compared with those without plaque and ECP in the first or second tertiles.
CONCLUSIONS: High ECP is associated with increased incidence of IS. The association between ECP and IS was also present in the subgroup with carotid plaque.
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- author
- Sundström, Johannes ; Söderholm, Martin LU ; Borné, Yan LU ; Nilsson, Jan LU ; Persson, Margaretha LU ; Östling, Gerd LU ; Melander, Olle LU ; Orho-Melander, Marju LU and Engström, Gunnar LU
- organization
-
- Cardiovascular Research - Epidemiology (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Internal Medicine - Epidemiology (research group)
- Cardiovascular Research - Hypertension (research group)
- Department of Clinical Sciences, Malmö
- Diabetes - Cardiovascular Disease (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2017-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cohort studies, eosinophil cationic protein, epidemiology, risk factors, stroke
- in
- Stroke
- volume
- 48
- issue
- 10
- pages
- 7 pages
- publisher
- American Heart Association
- external identifiers
-
- scopus:85030995981
- pmid:28904229
- wos:000411572500030
- ISSN
- 1524-4628
- DOI
- 10.1161/STROKEAHA.117.018450
- language
- English
- LU publication?
- yes
- id
- 4928e124-d423-45c4-a483-cb2321ecb094
- date added to LUP
- 2017-11-07 09:19:40
- date last changed
- 2024-09-16 11:50:38
@article{4928e124-d423-45c4-a483-cb2321ecb094, abstract = {{<p>BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.</p><p>METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A total of 4706 subjects with no history of stroke were included (40% men; mean age, 57.5 years). Carotid plaque was determined by B-mode ultrasound of the right carotid artery. Incidence of stroke was followed up during a mean period of 16.5 years in relation to plasma ECP levels.</p><p>RESULTS: Subjects in the third tertile (versus first tertile) of ECP tended to have higher prevalence of carotid plaque (odds ratio: 1.18; 95% confidence interval: 1.003-1.39; P=0.044 after multivariate adjustments). A total of 258 subjects were diagnosed with ischemic stroke (IS) during follow-up. ECP was associated with increased incidence of IS after risk factor adjustment (hazard ratio, 1.57; 95% confidence interval: 1.13-2.18; for third versus first tertile; P=0.007). High ECP was associated with increased risk of IS in subjects with carotid plaque. The risk factor-adjusted hazard ratio for IS was 1.86 (95% confidence interval: 1.32-2.63) in subjects with carotid plaque and ECP in the top tertile, compared with those without plaque and ECP in the first or second tertiles.</p><p>CONCLUSIONS: High ECP is associated with increased incidence of IS. The association between ECP and IS was also present in the subgroup with carotid plaque.</p>}}, author = {{Sundström, Johannes and Söderholm, Martin and Borné, Yan and Nilsson, Jan and Persson, Margaretha and Östling, Gerd and Melander, Olle and Orho-Melander, Marju and Engström, Gunnar}}, issn = {{1524-4628}}, keywords = {{cohort studies; eosinophil cationic protein; epidemiology; risk factors; stroke}}, language = {{eng}}, month = {{10}}, number = {{10}}, pages = {{2686--2692}}, publisher = {{American Heart Association}}, series = {{Stroke}}, title = {{Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke}}, url = {{http://dx.doi.org/10.1161/STROKEAHA.117.018450}}, doi = {{10.1161/STROKEAHA.117.018450}}, volume = {{48}}, year = {{2017}}, }