The prognostic role of cancer stem cell markers for long-term outcome after resection of colonic liver metastases
(2018) In Anticancer research 38(1). p.313-320- Abstract
Background/Aim: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection. Materials and Methods: Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemistry analysis. OS and DFS were compared between marker-positive and marker-negative patients. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: CD133-positive patients had a worse DFS than CD133-negative patients, with a median DFS of 12 and 25 months (p=0.051). Multivariate analysis selected CD133... (More)
Background/Aim: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection. Materials and Methods: Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemistry analysis. OS and DFS were compared between marker-positive and marker-negative patients. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: CD133-positive patients had a worse DFS than CD133-negative patients, with a median DFS of 12 and 25 months (p=0.051). Multivariate analysis selected CD133 expression as a significant predictor for DFS. CD44 and CD24 were not found to predict OS or DFS. Conclusion: CD133 expression in colonic liver metastases is a negative prognostic factor for DFS after liver resection. In the future, CD133 could be used as a biomarker for risk stratification, and possibly for developing novel targeted therapy.
(Less)
- author
- Spelt, Lidewij LU ; Sasor, Agata ; Ansari, Daniel LU ; Hilmersson, Katarzyna Said LU and Andersson, Roland LU
- organization
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Colonic neoplasms, Disease-free survival, Liver resection, Metastasis, Neoplastic stem cells, Survival analysis
- in
- Anticancer research
- volume
- 38
- issue
- 1
- pages
- 8 pages
- publisher
- International Institute of Cancer Research
- external identifiers
-
- pmid:29277789
- scopus:85039776960
- ISSN
- 0250-7005
- DOI
- 10.21873/anticanres.12224
- language
- English
- LU publication?
- yes
- id
- 4f3fad25-183c-426c-89a2-08f8c95b0f8d
- date added to LUP
- 2018-01-24 13:47:53
- date last changed
- 2024-07-08 08:28:41
@article{4f3fad25-183c-426c-89a2-08f8c95b0f8d, abstract = {{<p>Background/Aim: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection. Materials and Methods: Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemistry analysis. OS and DFS were compared between marker-positive and marker-negative patients. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: CD133-positive patients had a worse DFS than CD133-negative patients, with a median DFS of 12 and 25 months (p=0.051). Multivariate analysis selected CD133 expression as a significant predictor for DFS. CD44 and CD24 were not found to predict OS or DFS. Conclusion: CD133 expression in colonic liver metastases is a negative prognostic factor for DFS after liver resection. In the future, CD133 could be used as a biomarker for risk stratification, and possibly for developing novel targeted therapy.</p>}}, author = {{Spelt, Lidewij and Sasor, Agata and Ansari, Daniel and Hilmersson, Katarzyna Said and Andersson, Roland}}, issn = {{0250-7005}}, keywords = {{Colonic neoplasms; Disease-free survival; Liver resection; Metastasis; Neoplastic stem cells; Survival analysis}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{313--320}}, publisher = {{International Institute of Cancer Research}}, series = {{Anticancer research}}, title = {{The prognostic role of cancer stem cell markers for long-term outcome after resection of colonic liver metastases}}, url = {{http://dx.doi.org/10.21873/anticanres.12224}}, doi = {{10.21873/anticanres.12224}}, volume = {{38}}, year = {{2018}}, }