Heparin for the treatment of thrombosis in preterm and term neonates
(2016) In Cochrane Database of Systematic Reviews 2016(5).- Abstract
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess whether heparin treatment (both UFH and LMWH) in preterm and term newborn infants with diagnosed thrombosis reduces the rate of mortality and morbidity. The intervention will be compared to placebo or no treatment. In addition, the safety of heparin therapy (both UFH and LMWH) will be assessed for potential harms. Subgroup analyses will be performed regarding gestational age, birth weight, mode of thrombus diagnosis, presence of central line, positive family history for genetic disorders (thrombophilia, deficiency of protein S and protein C, MTHFR mutation), route of heparin administration, type of heparin used, and location of thrombus... (More)
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess whether heparin treatment (both UFH and LMWH) in preterm and term newborn infants with diagnosed thrombosis reduces the rate of mortality and morbidity. The intervention will be compared to placebo or no treatment. In addition, the safety of heparin therapy (both UFH and LMWH) will be assessed for potential harms. Subgroup analyses will be performed regarding gestational age, birth weight, mode of thrombus diagnosis, presence of central line, positive family history for genetic disorders (thrombophilia, deficiency of protein S and protein C, MTHFR mutation), route of heparin administration, type of heparin used, and location of thrombus (see Subgroup analysis and investigation of heterogeneity).
(Less)
- author
- Romantsik, Olga LU ; Bruschettini, Matteo LU ; Zappettini, Simona ; Ramenghi, Luca Antonio and Calevo, Maria Grazia
- organization
- publishing date
- 2016-05-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cochrane Database of Systematic Reviews
- volume
- 2016
- issue
- 5
- article number
- CD012185
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:84965048628
- ISSN
- 1469-493X
- DOI
- 10.1002/14651858.CD012185
- language
- English
- LU publication?
- yes
- id
- 50fcce37-dfd9-4f30-bd79-e553ddc8ff92
- date added to LUP
- 2016-05-31 15:06:48
- date last changed
- 2022-01-30 03:48:35
@article{50fcce37-dfd9-4f30-bd79-e553ddc8ff92, abstract = {{<p>This is the protocol for a review and there is no abstract. The objectives are as follows: To assess whether heparin treatment (both UFH and LMWH) in preterm and term newborn infants with diagnosed thrombosis reduces the rate of mortality and morbidity. The intervention will be compared to placebo or no treatment. In addition, the safety of heparin therapy (both UFH and LMWH) will be assessed for potential harms. Subgroup analyses will be performed regarding gestational age, birth weight, mode of thrombus diagnosis, presence of central line, positive family history for genetic disorders (thrombophilia, deficiency of protein S and protein C, MTHFR mutation), route of heparin administration, type of heparin used, and location of thrombus (see Subgroup analysis and investigation of heterogeneity).</p>}}, author = {{Romantsik, Olga and Bruschettini, Matteo and Zappettini, Simona and Ramenghi, Luca Antonio and Calevo, Maria Grazia}}, issn = {{1469-493X}}, language = {{eng}}, month = {{05}}, number = {{5}}, publisher = {{Wiley-Blackwell}}, series = {{Cochrane Database of Systematic Reviews}}, title = {{Heparin for the treatment of thrombosis in preterm and term neonates}}, url = {{http://dx.doi.org/10.1002/14651858.CD012185}}, doi = {{10.1002/14651858.CD012185}}, volume = {{2016}}, year = {{2016}}, }