Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease
(2018) In Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 38(9). p.1391-1417- Abstract
Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the... (More)
Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.
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- author
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article
- in
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- volume
- 38
- issue
- 9
- pages
- 1391 - 1417
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85046007845
- pmid:28816594
- ISSN
- 1559-7016
- DOI
- 10.1177/0271678X17721830
- project
- Optimisation and Validation of Dynamic Susceptibility Contrast MRI
- language
- English
- LU publication?
- yes
- id
- 516e4a20-8089-412c-b324-4a5e59a7bc6e
- date added to LUP
- 2017-11-23 13:18:10
- date last changed
- 2024-08-19 09:29:12
@article{516e4a20-8089-412c-b324-4a5e59a7bc6e, abstract = {{<p>Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.</p>}}, author = {{Donahue, Manus J and Achten, Eric and Cogswell, Petrice M and De Leeuw, Frank-Erik and Derdeyn, Colin P and Dijkhuizen, Rick M and Fan, Audrey P and Ghaznawi, Rashid and Heit, Jeremy J and Ikram, M Arfan and Jezzard, Peter and Jordan, Lori C and Jouvent, Eric and Knutsson, Linda and Leigh, Richard and Liebeskind, David S and Lin, Weili and Okell, Thomas W and Qureshi, Adnan I and Stagg, Charlotte J and van Osch, Matthias Jp and van Zijl, Peter Cm and Watchmaker, Jennifer M and Wintermark, Max and Wu, Ona and Zaharchuk, Greg and Zhou, Jinyuan and Hendrikse, Jeroen}}, issn = {{1559-7016}}, keywords = {{Journal Article}}, language = {{eng}}, number = {{9}}, pages = {{1391--1417}}, publisher = {{Nature Publishing Group}}, series = {{Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}}, title = {{Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease}}, url = {{http://dx.doi.org/10.1177/0271678X17721830}}, doi = {{10.1177/0271678X17721830}}, volume = {{38}}, year = {{2018}}, }