TRIM28 and the control of transposable elements in the brain
Grassi, Daniela A. LU ; Jönsson, Marie E. LU ; Brattås, Per Ludvik LU and Jakobsson, Johan LU
(2019)
In Brain Research
1705.
p.43-47
- Abstract
TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of transposable elements (TE). Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects through the regulation of transcriptional networks. Here, we provide an overview of TRIM28-related functions, highlighting the role of controlling TEs in neural progenitor cells and discuss how this mechanism may have contributed to the evolution of the complex human brain. Finally, we outline future considerations for the field.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/53d6900a-ad67-41a5-a349-5ae9eeacb6c4
- author
- Grassi, Daniela A.
LU
; Jönsson, Marie E.
LU
; Brattås, Per Ludvik
LU
and Jakobsson, Johan
LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Epigenetics, KRAB-ZFPs, Neurodevelopment, Transposable elements
- in
- Brain Research
- volume
- 1705
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:29522722
- pmid:29522722
- scopus:85043498068
- ISSN
- 0006-8993
- DOI
- 10.1016/j.brainres.2018.02.043
- language
- English
- LU publication?
- yes
- id
- 53d6900a-ad67-41a5-a349-5ae9eeacb6c4
- date added to LUP
- 2018-03-27 11:13:43
- date last changed
- 2024-04-01 03:21:43
@article{53d6900a-ad67-41a5-a349-5ae9eeacb6c4,
abstract = {{<p>TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of transposable elements (TE). Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects through the regulation of transcriptional networks. Here, we provide an overview of TRIM28-related functions, highlighting the role of controlling TEs in neural progenitor cells and discuss how this mechanism may have contributed to the evolution of the complex human brain. Finally, we outline future considerations for the field.</p>}},
author = {{Grassi, Daniela A. and Jönsson, Marie E. and Brattås, Per Ludvik and Jakobsson, Johan}},
issn = {{0006-8993}},
keywords = {{Epigenetics; KRAB-ZFPs; Neurodevelopment; Transposable elements}},
language = {{eng}},
pages = {{43--47}},
publisher = {{Elsevier}},
series = {{Brain Research}},
title = {{TRIM28 and the control of transposable elements in the brain}},
url = {{http://dx.doi.org/10.1016/j.brainres.2018.02.043}},
doi = {{10.1016/j.brainres.2018.02.043}},
volume = {{1705}},
year = {{2019}},
}