Automatic T2* determination for quantification of iron load in heart and liver : a comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods
(2017) In Clinical Physiology and Functional Imaging 37(3). p.299-304- Abstract
PURPOSE: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients.
METHODS: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm(3) , 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference.
RESULTS: Phantoms: MLE showed low variability between NSA1... (More)
PURPOSE: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients.
METHODS: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm(3) , 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference.
RESULTS: Phantoms: MLE showed low variability between NSA1 and NSA32 (0·02 ± 0·29 ms, CI ±0·21 ms). Between methods, no difference was shown (MLE versus all: <0·31 ms, CI < ±0·35 ms).
PATIENTS: No differences were found between methods in heart (MLE versus all: <-0·22 ms, CI < ±0·75 ms) or liver (MLE versus all: <0·12 ms, CI < ±0·26 ms).
CONCLUSIONS: The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.
(Less)
- author
- Hedström, Erik LU ; Voigt, Tobias ; Greil, Gerald ; Schaeffter, Tobias and Nagel, Eike
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Physiology and Functional Imaging
- volume
- 37
- issue
- 3
- pages
- 299 - 304
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:84983121061
- pmid:26475530
- ISSN
- 1475-0961
- DOI
- 10.1111/cpf.12303
- language
- English
- LU publication?
- no
- id
- 56791212-7861-45dc-82d9-0999acb68596
- date added to LUP
- 2017-02-02 11:41:10
- date last changed
- 2023-02-24 22:46:37
@article{56791212-7861-45dc-82d9-0999acb68596, abstract = {{<p>PURPOSE: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients.</p><p>METHODS: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm(3) , 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference.</p><p>RESULTS: Phantoms: MLE showed low variability between NSA1 and NSA32 (0·02 ± 0·29 ms, CI ±0·21 ms). Between methods, no difference was shown (MLE versus all: <0·31 ms, CI < ±0·35 ms).</p><p>PATIENTS: No differences were found between methods in heart (MLE versus all: <-0·22 ms, CI < ±0·75 ms) or liver (MLE versus all: <0·12 ms, CI < ±0·26 ms).</p><p>CONCLUSIONS: The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.</p>}}, author = {{Hedström, Erik and Voigt, Tobias and Greil, Gerald and Schaeffter, Tobias and Nagel, Eike}}, issn = {{1475-0961}}, language = {{eng}}, number = {{3}}, pages = {{299--304}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Clinical Physiology and Functional Imaging}}, title = {{Automatic T2* determination for quantification of iron load in heart and liver : a comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods}}, url = {{http://dx.doi.org/10.1111/cpf.12303}}, doi = {{10.1111/cpf.12303}}, volume = {{37}}, year = {{2017}}, }