Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency
(1989) In Brain Research 496(1-2). p.141-147- Abstract
Peripheral nerve regeneration was studied in female Sprague-Dawley rats with streptozotocin-induced insulin deficiency. Nerve regeneration was provoked by a crush lesion on the sciatic nerve 21 days after the streptozotocin injection. The regeneration was assessed by a pinch test at different time-points after injury. The rate ofregeneration in insulin-deficient animals, 2.5 mm/day, was significantly lower than in control animals, 2.9 mm/day(P < 0.05). There was no difference in the initial delay, i.e. the period before regeneration attains a constant velocity. One group of insulin-deficient rats was treated with insulin during the regeneration period by means of implanted osmotic mini-pumps. This treatment prevented the decrease in... (More)
Peripheral nerve regeneration was studied in female Sprague-Dawley rats with streptozotocin-induced insulin deficiency. Nerve regeneration was provoked by a crush lesion on the sciatic nerve 21 days after the streptozotocin injection. The regeneration was assessed by a pinch test at different time-points after injury. The rate ofregeneration in insulin-deficient animals, 2.5 mm/day, was significantly lower than in control animals, 2.9 mm/day(P < 0.05). There was no difference in the initial delay, i.e. the period before regeneration attains a constant velocity. One group of insulin-deficient rats was treated with insulin during the regeneration period by means of implanted osmotic mini-pumps. This treatment prevented the decrease in regenerationsw. After 6 days the sciatic nerves of insulin-deficient rats had regenerated 12.3 ±0.3 mm (mean ±S.E.M.), while the corresponding value for insulin-treated rats was 15.7 ±0.6 mm (P > 0.01). The streptozotocin-treated rats were found to have a 39% reduction in the serum level of insulin-like 1 growth factor-I (IGF-I)_compared to control rats (0.33 ± 0.22 μg/ml and 0.54 ± ml respectively, (P < 0.001). Insulin treatment 1830 1732 during the regeneration period completely restored the IGF-I level back to normal.
(Less)
- author
- Ekström, Per A R LU ; Kanje, Martin LU and Skottner, Anna
- organization
- publishing date
- 1989-09-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diabetes, Insulin, Insulin-like growth factor-I, Nerve regeneration, Rat, Sciatic nerve, Somatomedin, Streptozotocin
- in
- Brain Research
- volume
- 496
- issue
- 1-2
- pages
- 141 - 147
- publisher
- Elsevier
- external identifiers
-
- scopus:0024340849
- pmid:2529948
- ISSN
- 0006-8993
- DOI
- 10.1016/0006-8993(89)91060-3
- language
- English
- LU publication?
- yes
- id
- 5a49e4bb-fc17-4fbf-ac9a-b6ecf5aba1cf
- date added to LUP
- 2016-12-07 14:31:47
- date last changed
- 2024-01-04 18:19:14
@article{5a49e4bb-fc17-4fbf-ac9a-b6ecf5aba1cf, abstract = {{<p>Peripheral nerve regeneration was studied in female Sprague-Dawley rats with streptozotocin-induced insulin deficiency. Nerve regeneration was provoked by a crush lesion on the sciatic nerve 21 days after the streptozotocin injection. The regeneration was assessed by a pinch test at different time-points after injury. The rate ofregeneration in insulin-deficient animals, 2.5 mm/day, was significantly lower than in control animals, 2.9 mm/day(P < 0.05). There was no difference in the initial delay, i.e. the period before regeneration attains a constant velocity. One group of insulin-deficient rats was treated with insulin during the regeneration period by means of implanted osmotic mini-pumps. This treatment prevented the decrease in regenerationsw. After 6 days the sciatic nerves of insulin-deficient rats had regenerated 12.3 ±0.3 mm (mean ±S.E.M.), while the corresponding value for insulin-treated rats was 15.7 ±0.6 mm (P > 0.01). The streptozotocin-treated rats were found to have a 39% reduction in the serum level of insulin-like 1 growth factor-I (IGF-I)_compared to control rats (0.33 ± 0.22 μg/ml and 0.54 ± ml respectively, (P < 0.001). Insulin treatment 1830 1732 during the regeneration period completely restored the IGF-I level back to normal.</p>}}, author = {{Ekström, Per A R and Kanje, Martin and Skottner, Anna}}, issn = {{0006-8993}}, keywords = {{Diabetes; Insulin; Insulin-like growth factor-I; Nerve regeneration; Rat; Sciatic nerve; Somatomedin; Streptozotocin}}, language = {{eng}}, month = {{09}}, number = {{1-2}}, pages = {{141--147}}, publisher = {{Elsevier}}, series = {{Brain Research}}, title = {{Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency}}, url = {{http://dx.doi.org/10.1016/0006-8993(89)91060-3}}, doi = {{10.1016/0006-8993(89)91060-3}}, volume = {{496}}, year = {{1989}}, }