Peripheral nerve regeneration in Gore-tex chambers
(1988) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 22(3). p.10-207- Abstract
Gore-tex chambers were used to bridge a 6 mm gap between the proximal and distal nerve stumps of a rat sciatic nerve. The wall structure of these chambers is characterized by "nodes" interconnected by smaller fibrils. Chambers with internodal distances of 5, 10 and 30 microns were used. Some 30 microns chambers were coated from the outside with Gore-tex (0.2 micron internodal distance) and others were coated from the inside. Regeneration after 12 weeks, as evidenced by muscle action potential recordings and light microscopy, was successful regardless of what type of chamber had been used. The organization of the nerve structure varied among different chamber types. A well organized coaxial nerve structure with myelinated axons was... (More)
Gore-tex chambers were used to bridge a 6 mm gap between the proximal and distal nerve stumps of a rat sciatic nerve. The wall structure of these chambers is characterized by "nodes" interconnected by smaller fibrils. Chambers with internodal distances of 5, 10 and 30 microns were used. Some 30 microns chambers were coated from the outside with Gore-tex (0.2 micron internodal distance) and others were coated from the inside. Regeneration after 12 weeks, as evidenced by muscle action potential recordings and light microscopy, was successful regardless of what type of chamber had been used. The organization of the nerve structure varied among different chamber types. A well organized coaxial nerve structure with myelinated axons was observed if inner-coated chambers were used. In chambers that were not coated or in outer-coated chambers tissue completely filled the chambers, and myelinated axons were arranged in mini-fascicles surrounded by loose connective tissue.
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- author
- Danielsen, N LU ; Williams, L R ; Dahlin, L B LU ; Varon, S and Lundborg, G LU
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Axons, Diffusion Chambers, Culture, Female, Muscles, Nerve Fibers, Nerve Regeneration, Peripheral Nerves, Polytetrafluoroethylene, Rats, Rats, Inbred Strains, Sciatic Nerve, Journal Article, Research Support, Non-U.S. Gov't
- in
- Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
- volume
- 22
- issue
- 3
- pages
- 10 - 207
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:3252448
- scopus:0024270542
- ISSN
- 0284-4311
- language
- English
- LU publication?
- yes
- id
- 5b2ebbaf-3410-40cf-aebc-8abd9b3d56b1
- date added to LUP
- 2017-10-13 13:45:40
- date last changed
- 2024-01-14 07:23:06
@article{5b2ebbaf-3410-40cf-aebc-8abd9b3d56b1, abstract = {{<p>Gore-tex chambers were used to bridge a 6 mm gap between the proximal and distal nerve stumps of a rat sciatic nerve. The wall structure of these chambers is characterized by "nodes" interconnected by smaller fibrils. Chambers with internodal distances of 5, 10 and 30 microns were used. Some 30 microns chambers were coated from the outside with Gore-tex (0.2 micron internodal distance) and others were coated from the inside. Regeneration after 12 weeks, as evidenced by muscle action potential recordings and light microscopy, was successful regardless of what type of chamber had been used. The organization of the nerve structure varied among different chamber types. A well organized coaxial nerve structure with myelinated axons was observed if inner-coated chambers were used. In chambers that were not coated or in outer-coated chambers tissue completely filled the chambers, and myelinated axons were arranged in mini-fascicles surrounded by loose connective tissue.</p>}}, author = {{Danielsen, N and Williams, L R and Dahlin, L B and Varon, S and Lundborg, G}}, issn = {{0284-4311}}, keywords = {{Animals; Axons; Diffusion Chambers, Culture; Female; Muscles; Nerve Fibers; Nerve Regeneration; Peripheral Nerves; Polytetrafluoroethylene; Rats; Rats, Inbred Strains; Sciatic Nerve; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{3}}, pages = {{10--207}}, publisher = {{Taylor & Francis}}, series = {{Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery}}, title = {{Peripheral nerve regeneration in Gore-tex chambers}}, volume = {{22}}, year = {{1988}}, }