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Cytopathologic Diagnosis of Small B-Cell Lymphomas

Raine, Juliet ; Hookway, Edward S. ; Farren, Timothy ; Ehinger, Mats LU ; Cozzolino, Immacolata and Calaminici, Mariarita (2026) In Acta Cytologica p.1-16
Abstract

Abstract – Background: Cytologic examination of lymph nodes and serous effusions is of value in the diagnosis of small cell lymphomas. The World Health Organisation (WHO) has recently published a reporting system relating to the cytologic examination of lymph nodes, spleen, and thymus to standardise the approach to reporting such specimens. Summary: An overview of the WHO reporting system is given with particular reference to the diagnosis of small B-cell lymphomas. The role of rapid on-site evaluation and ancillary testing is discussed. The cytomorphological features of specific small B-cell lymphomas and associated ancillary testing are described. Key Messages: The WHO reporting system provides a standardised approach to the reporting... (More)

Abstract – Background: Cytologic examination of lymph nodes and serous effusions is of value in the diagnosis of small cell lymphomas. The World Health Organisation (WHO) has recently published a reporting system relating to the cytologic examination of lymph nodes, spleen, and thymus to standardise the approach to reporting such specimens. Summary: An overview of the WHO reporting system is given with particular reference to the diagnosis of small B-cell lymphomas. The role of rapid on-site evaluation and ancillary testing is discussed. The cytomorphological features of specific small B-cell lymphomas and associated ancillary testing are described. Key Messages: The WHO reporting system provides a standardised approach to the reporting of cytological specimens from lymph nodes, the spleen, and the thymus. Small B-cell lymphomas pose a challenge to the cytopathologist due to their morphologic overlap with each other and reactive conditions. The importance of correlation and integration of cytomorphological appearances with clinical features and ancillary testing modalities to obtain a final diagnosis is emphasised. The present review includes a description of cytomorphological features according to pattern recognition and provides an overview of diagnostic criteria for specific entities based on cytomorphology alone and in combination with ancillary tests in different clinical settings discussing differential diagnoses and potential pitfalls.

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author
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organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
Ancillary techniques, Cytology, Lymphoma, Small B-cell lymphomas
in
Acta Cytologica
pages
16 pages
publisher
Karger
external identifiers
  • scopus:105031966221
  • pmid:41490300
ISSN
0001-5547
DOI
10.1159/000550229
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2026 S. Karger AG, Basel
id
5fa41343-2a95-46a2-a3ed-5b135e88a41d
date added to LUP
2026-05-11 15:22:19
date last changed
2026-05-12 08:08:48
@article{5fa41343-2a95-46a2-a3ed-5b135e88a41d,
  abstract     = {{<p>Abstract – Background: Cytologic examination of lymph nodes and serous effusions is of value in the diagnosis of small cell lymphomas. The World Health Organisation (WHO) has recently published a reporting system relating to the cytologic examination of lymph nodes, spleen, and thymus to standardise the approach to reporting such specimens. Summary: An overview of the WHO reporting system is given with particular reference to the diagnosis of small B-cell lymphomas. The role of rapid on-site evaluation and ancillary testing is discussed. The cytomorphological features of specific small B-cell lymphomas and associated ancillary testing are described. Key Messages: The WHO reporting system provides a standardised approach to the reporting of cytological specimens from lymph nodes, the spleen, and the thymus. Small B-cell lymphomas pose a challenge to the cytopathologist due to their morphologic overlap with each other and reactive conditions. The importance of correlation and integration of cytomorphological appearances with clinical features and ancillary testing modalities to obtain a final diagnosis is emphasised. The present review includes a description of cytomorphological features according to pattern recognition and provides an overview of diagnostic criteria for specific entities based on cytomorphology alone and in combination with ancillary tests in different clinical settings discussing differential diagnoses and potential pitfalls.</p>}},
  author       = {{Raine, Juliet and Hookway, Edward S. and Farren, Timothy and Ehinger, Mats and Cozzolino, Immacolata and Calaminici, Mariarita}},
  issn         = {{0001-5547}},
  keywords     = {{Ancillary techniques; Cytology; Lymphoma; Small B-cell lymphomas}},
  language     = {{eng}},
  pages        = {{1--16}},
  publisher    = {{Karger}},
  series       = {{Acta Cytologica}},
  title        = {{Cytopathologic Diagnosis of Small B-Cell Lymphomas}},
  url          = {{http://dx.doi.org/10.1159/000550229}},
  doi          = {{10.1159/000550229}},
  year         = {{2026}},
}