Adverse Lipid and Inflammatory Changes in Young Nondiabetic First-Degree Relatives of Type 1-Diabetic Patients
(2018) 52nd Annual meeting of the Association for European Paediatric and Congenital Caardiology In Cardiology in the Young 28(S1). p.43-44- Abstract
- Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were... (More)
- Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were assessed in up to 116 non-diabetic first-degree relatives (FDR; mean age: 12.6 years; 56 female) of patients with T1D and in up to 43 age-matched control individuals (mean age: 13.3 years; 23 female) without heredity for cardiovascular risk factors. The number and type of clinically manifest acute infections during the past year were obtained via a questionnaire validated in our previous studies.Results: There was no difference in age, gender, body mass index, arterial blood pressure and C- peptide levels between the FDR and control groups (p>0.2). Also, there was no significant difference in SI (p=0.2), CAC (p=0.1) and CA-IMT (p=0.9) between the groups. In the FDR group, plasma CRP and LDL- cholesterol (LDL-C) were increased (p<0.05 for both) and HDL-C was decreased (p<0.0001) as compared to the control group. The changes in LDL-C and HDL-C were most marked in FDR individuals with ≥ 4 acute respiratory infections during the past year (Figure).Conclusion: Adverse lipidemic and inflammatory changes are present in healthy non-diabetic first- degree relatives of T1D patients, probably related to their genetic susceptibility to this disease. Further analyses of additional indices of peripheral arterial function in these groups are under way. (Less)
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https://lup.lub.lu.se/record/6255e459-8fcc-46d0-a460-4291149361a2
- author
- Englund, Emma LU ; Maxedius, Annica LU ; Odermarsky, Michal LU and Liuba, Petru LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cardiology in the Young
- volume
- 28
- issue
- S1
- article number
- MP1-8
- pages
- 43 - 44
- publisher
- Cambridge University Press
- conference name
- 52nd Annual meeting of the Association for European Paediatric and Congenital Caardiology
- conference location
- Athens, Greece
- conference dates
- 2018-05-09 - 2018-05-12
- ISSN
- 1467-1107
- DOI
- 10.1017/S1047951118000318
- language
- English
- LU publication?
- yes
- id
- 6255e459-8fcc-46d0-a460-4291149361a2
- date added to LUP
- 2018-05-13 20:17:58
- date last changed
- 2021-03-22 16:20:29
@misc{6255e459-8fcc-46d0-a460-4291149361a2, abstract = {{Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were assessed in up to 116 non-diabetic first-degree relatives (FDR; mean age: 12.6 years; 56 female) of patients with T1D and in up to 43 age-matched control individuals (mean age: 13.3 years; 23 female) without heredity for cardiovascular risk factors. The number and type of clinically manifest acute infections during the past year were obtained via a questionnaire validated in our previous studies.Results: There was no difference in age, gender, body mass index, arterial blood pressure and C- peptide levels between the FDR and control groups (p>0.2). Also, there was no significant difference in SI (p=0.2), CAC (p=0.1) and CA-IMT (p=0.9) between the groups. In the FDR group, plasma CRP and LDL- cholesterol (LDL-C) were increased (p<0.05 for both) and HDL-C was decreased (p<0.0001) as compared to the control group. The changes in LDL-C and HDL-C were most marked in FDR individuals with ≥ 4 acute respiratory infections during the past year (Figure).Conclusion: Adverse lipidemic and inflammatory changes are present in healthy non-diabetic first- degree relatives of T1D patients, probably related to their genetic susceptibility to this disease. Further analyses of additional indices of peripheral arterial function in these groups are under way.}}, author = {{Englund, Emma and Maxedius, Annica and Odermarsky, Michal and Liuba, Petru}}, issn = {{1467-1107}}, language = {{eng}}, note = {{Conference Abstract}}, number = {{S1}}, pages = {{43--44}}, publisher = {{Cambridge University Press}}, series = {{Cardiology in the Young}}, title = {{Adverse Lipid and Inflammatory Changes in Young Nondiabetic First-Degree Relatives of Type 1-Diabetic Patients}}, url = {{http://dx.doi.org/10.1017/S1047951118000318}}, doi = {{10.1017/S1047951118000318}}, volume = {{28}}, year = {{2018}}, }