Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.
(1992) In Arthritis and Rheumatism 35(4). p.385-390- Abstract
- OBJECTIVE:
To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.
METHODS:
Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.
RESULTS:
Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with... (More) - OBJECTIVE:
To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.
METHODS:
Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.
RESULTS:
Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with advanced cartilage destruction. In reactive arthritis, release of the glycosaminoglycan-rich region predominated.
CONCLUSION:
These findings indicate that the hyaluronan-binding region is initially retained in the tissue during the development of cartilage destruction. The combined analysis of these markers offers a new avenue for assessment of the degree of cartilage damage in arthritis.
(Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/634372ed-967f-44f5-b210-7b27ebb8476b
- author
- Saxne, Tore LU and Heinegård, Dick LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Synovial fluid, proteoglycans
- in
- Arthritis and Rheumatism
- volume
- 35
- issue
- 4
- pages
- 385 - 390
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0026710173
- ISSN
- 1529-0131
- language
- English
- LU publication?
- yes
- id
- 634372ed-967f-44f5-b210-7b27ebb8476b
- date added to LUP
- 2016-05-07 09:44:05
- date last changed
- 2021-01-03 05:10:35
@article{634372ed-967f-44f5-b210-7b27ebb8476b,
abstract = {{OBJECTIVE: <br/><br/>To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.<br/><br/>METHODS: <br/><br/>Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.<br/><br/>RESULTS: <br/><br/>Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with advanced cartilage destruction. In reactive arthritis, release of the glycosaminoglycan-rich region predominated.<br/><br/>CONCLUSION: <br/><br/>These findings indicate that the hyaluronan-binding region is initially retained in the tissue during the development of cartilage destruction. The combined analysis of these markers offers a new avenue for assessment of the degree of cartilage damage in arthritis.<br/>}},
author = {{Saxne, Tore and Heinegård, Dick}},
issn = {{1529-0131}},
keywords = {{Synovial fluid; proteoglycans}},
language = {{eng}},
number = {{4}},
pages = {{385--390}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Arthritis and Rheumatism}},
title = {{Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.}},
volume = {{35}},
year = {{1992}},
}