Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: Six-month study
(2007) In International Journal for Vitamin and Nutrition Research 77(2). p.89-97- Abstract
- Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1,68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as lumbar spine bone mineral density (BMD) in a randomized, parallel group, double-blind, 6-month study conducted on 76 postmenopausal women with osteopenia. The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006). The differences in CTX between study groups were statistically significant after 12 weeks and 24 weeks. The... (More)
- Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1,68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as lumbar spine bone mineral density (BMD) in a randomized, parallel group, double-blind, 6-month study conducted on 76 postmenopausal women with osteopenia. The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006). The differences in CTX between study groups were statistically significant after 12 weeks and 24 weeks. The OC serum level was not affected by treatments. The BMD of the AKG-Ca group increased 1.6% from baseline; however, the difference between treatment groups was estimated as 0.9% (non-significant). This study suggests the potential usefulness of AKG-Ca in osteopenic postmenopausal women. AKG-Ca induced beneficial changes in serum CTX, which was consistent with preserving the bone mass in the lumbar spine; however, the long-term effect needs to be further investigated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/647746
- author
- Filip, Rafal S. ; Pierzynowski, Stefan LU ; Lindegard, Birger ; Wernerman, Jan ; Haratym-Maj, Agnieszka and Podgurniak, Malgorzata
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- osteocalcin, collagen, alpha-ketoglutarate, C-terminal cross-linking telopeptide of type I, osteopenia, bone mineral density (BDM)
- in
- International Journal for Vitamin and Nutrition Research
- volume
- 77
- issue
- 2
- pages
- 89 - 97
- publisher
- Verlag Hans Huber
- external identifiers
-
- wos:000247546300003
- scopus:34250891909
- ISSN
- 0300-9831
- DOI
- 10.1024/0300-9831.77.2.89
- language
- English
- LU publication?
- yes
- id
- b5410b14-f340-4a9f-8972-160d589afa54 (old id 647746)
- date added to LUP
- 2016-04-01 16:15:13
- date last changed
- 2022-03-14 23:13:44
@article{b5410b14-f340-4a9f-8972-160d589afa54, abstract = {{Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1,68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as lumbar spine bone mineral density (BMD) in a randomized, parallel group, double-blind, 6-month study conducted on 76 postmenopausal women with osteopenia. The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006). The differences in CTX between study groups were statistically significant after 12 weeks and 24 weeks. The OC serum level was not affected by treatments. The BMD of the AKG-Ca group increased 1.6% from baseline; however, the difference between treatment groups was estimated as 0.9% (non-significant). This study suggests the potential usefulness of AKG-Ca in osteopenic postmenopausal women. AKG-Ca induced beneficial changes in serum CTX, which was consistent with preserving the bone mass in the lumbar spine; however, the long-term effect needs to be further investigated.}}, author = {{Filip, Rafal S. and Pierzynowski, Stefan and Lindegard, Birger and Wernerman, Jan and Haratym-Maj, Agnieszka and Podgurniak, Malgorzata}}, issn = {{0300-9831}}, keywords = {{osteocalcin; collagen; alpha-ketoglutarate; C-terminal cross-linking telopeptide of type I; osteopenia; bone mineral density (BDM)}}, language = {{eng}}, number = {{2}}, pages = {{89--97}}, publisher = {{Verlag Hans Huber}}, series = {{International Journal for Vitamin and Nutrition Research}}, title = {{Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: Six-month study}}, url = {{http://dx.doi.org/10.1024/0300-9831.77.2.89}}, doi = {{10.1024/0300-9831.77.2.89}}, volume = {{77}}, year = {{2007}}, }