Wear particles generated from studded tires and pavement induces inflammatory reactions in mouse macrophage cells
(2007) In Chemical Research in Toxicology 20(6). p.937-946- Abstract
- Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles generated from traffic have been recognized as a major contributing source to the overall particle load, especially in the Nordic countries where studded tires are used. The aim of this study was to further investigate and compare the ability to induce inflammatory mediators of different traffic-related wear particles collected from an urban street, a... (More)
- Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles generated from traffic have been recognized as a major contributing source to the overall particle load, especially in the Nordic countries where studded tires are used. The aim of this study was to further investigate and compare the ability to induce inflammatory mediators of different traffic-related wear particles collected from an urban street, a subway station, and studded tire-pavement wear. Inflammatory effects were measured as induction of nitric oxide (NO), IL-6, TNF-alpha, arachidonic acid (AA), and lipid peroxidation after exposure of the murine macrophage like cell line RAW 264.7. In addition, the redox potential of the particles was measured in a cell-free system. The results show that all particles tested induce IL-6, TNF-alpha, and NO, and those from the urban street were the most potent ones. In contrast, particles collected from a subway station were most potent to induce lipid peroxidation, AA release, and formation of ROS. Particles from studded tire-pavement wear, generated using a road simulator, were able to induce inflammatory cytokines, NO, lipid peroxidation, and ROS formation. Interestingly, particles generated from pavement containing granite as the main stone material were more potent than those generated from pavement containing quartzite as the main stone material. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/648549
- author
- Lindbom, John ; Gustafsson, Mats ; Blomqvist, Goran ; Dahl, Andreas LU ; Gudmundsson, Anders LU ; Swietlicki, Erik LU and Ljungman, Anders G.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Chemical Research in Toxicology
- volume
- 20
- issue
- 6
- pages
- 937 - 946
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000247304200012
- scopus:34447126941
- ISSN
- 1520-5010
- DOI
- 10.1021/tx700018z
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007), Ergonomics and Aerosol Technology (011025002)
- id
- 9fb56587-693b-4f97-bbb8-3195b23dd69f (old id 648549)
- date added to LUP
- 2016-04-01 11:49:04
- date last changed
- 2022-03-20 19:22:45
@article{9fb56587-693b-4f97-bbb8-3195b23dd69f, abstract = {{Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles generated from traffic have been recognized as a major contributing source to the overall particle load, especially in the Nordic countries where studded tires are used. The aim of this study was to further investigate and compare the ability to induce inflammatory mediators of different traffic-related wear particles collected from an urban street, a subway station, and studded tire-pavement wear. Inflammatory effects were measured as induction of nitric oxide (NO), IL-6, TNF-alpha, arachidonic acid (AA), and lipid peroxidation after exposure of the murine macrophage like cell line RAW 264.7. In addition, the redox potential of the particles was measured in a cell-free system. The results show that all particles tested induce IL-6, TNF-alpha, and NO, and those from the urban street were the most potent ones. In contrast, particles collected from a subway station were most potent to induce lipid peroxidation, AA release, and formation of ROS. Particles from studded tire-pavement wear, generated using a road simulator, were able to induce inflammatory cytokines, NO, lipid peroxidation, and ROS formation. Interestingly, particles generated from pavement containing granite as the main stone material were more potent than those generated from pavement containing quartzite as the main stone material.}}, author = {{Lindbom, John and Gustafsson, Mats and Blomqvist, Goran and Dahl, Andreas and Gudmundsson, Anders and Swietlicki, Erik and Ljungman, Anders G.}}, issn = {{1520-5010}}, language = {{eng}}, number = {{6}}, pages = {{937--946}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Chemical Research in Toxicology}}, title = {{Wear particles generated from studded tires and pavement induces inflammatory reactions in mouse macrophage cells}}, url = {{http://dx.doi.org/10.1021/tx700018z}}, doi = {{10.1021/tx700018z}}, volume = {{20}}, year = {{2007}}, }