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Dynamic extraction coupled on-line to liquid chromatography with a parallel sampling interface—a proof of concept for monitoring extraction kinetics

Sun, Mingzhe LU ; Al-hamimi, Said LU ; Sandahl, Margareta LU and Turner, Charlotta LU (2019) In Analytical and Bioanalytical Chemistry 411(16). p.3675-3683
Abstract

On-line hyphenation of extraction with chromatography has been explored in several different types of combinations. However, monitoring the complete process of a dynamic, continuous-flow extraction is not possible with any hyphenated system reported so far. The current work demonstrates that this challenging task can be effectively fulfilled by using a parallel sampling interface, which mimics the concept of comprehensive two-dimensional chromatography. In this study, pressurised hot water extraction was coupled on-line with ultra-high-performance liquid chromatography. The set-up was utilised in a kinetic study of dynamic pressurised hot water extraction of curcuminoids from turmeric powder. Compound-specific extraction curves were... (More)

On-line hyphenation of extraction with chromatography has been explored in several different types of combinations. However, monitoring the complete process of a dynamic, continuous-flow extraction is not possible with any hyphenated system reported so far. The current work demonstrates that this challenging task can be effectively fulfilled by using a parallel sampling interface, which mimics the concept of comprehensive two-dimensional chromatography. In this study, pressurised hot water extraction was coupled on-line with ultra-high-performance liquid chromatography. The set-up was utilised in a kinetic study of dynamic pressurised hot water extraction of curcuminoids from turmeric powder. Compound-specific extraction curves were obtained, which clearly indicated the rate-limiting factors of the extraction processes under different conditions. Additionally, thermal degradation of curcumin during the extraction could also be demonstrated in some of the extractions.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Curcuminoids, Dynamic extraction, Liquid chromatography, On-line hyphenation, Parallel sampling, Turmeric powder
in
Analytical and Bioanalytical Chemistry
volume
411
issue
16
pages
3675 - 3683
publisher
Springer
external identifiers
  • pmid:31062062
  • scopus:85065440341
ISSN
1618-2642
DOI
10.1007/s00216-019-01849-4
language
English
LU publication?
yes
id
672a88f9-8be9-4fad-9e67-38ff9fe7de70
date added to LUP
2019-05-27 08:27:04
date last changed
2024-02-15 09:39:37
@article{672a88f9-8be9-4fad-9e67-38ff9fe7de70,
  abstract     = {{<p>On-line hyphenation of extraction with chromatography has been explored in several different types of combinations. However, monitoring the complete process of a dynamic, continuous-flow extraction is not possible with any hyphenated system reported so far. The current work demonstrates that this challenging task can be effectively fulfilled by using a parallel sampling interface, which mimics the concept of comprehensive two-dimensional chromatography. In this study, pressurised hot water extraction was coupled on-line with ultra-high-performance liquid chromatography. The set-up was utilised in a kinetic study of dynamic pressurised hot water extraction of curcuminoids from turmeric powder. Compound-specific extraction curves were obtained, which clearly indicated the rate-limiting factors of the extraction processes under different conditions. Additionally, thermal degradation of curcumin during the extraction could also be demonstrated in some of the extractions.</p>}},
  author       = {{Sun, Mingzhe and Al-hamimi, Said and Sandahl, Margareta and Turner, Charlotta}},
  issn         = {{1618-2642}},
  keywords     = {{Curcuminoids; Dynamic extraction; Liquid chromatography; On-line hyphenation; Parallel sampling; Turmeric powder}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{16}},
  pages        = {{3675--3683}},
  publisher    = {{Springer}},
  series       = {{Analytical and Bioanalytical Chemistry}},
  title        = {{Dynamic extraction coupled on-line to liquid chromatography with a parallel sampling interface—a proof of concept for monitoring extraction kinetics}},
  url          = {{http://dx.doi.org/10.1007/s00216-019-01849-4}},
  doi          = {{10.1007/s00216-019-01849-4}},
  volume       = {{411}},
  year         = {{2019}},
}