Smoking is a strong risk factor for rheumatoid nodules in early rheumatoid arthritis
(2006) In Annals of the Rheumatic Diseases 65(5). p.601-606- Abstract
- Objective: To examine whether smoking is a risk factor for rheumatoid nodules in early rheumatoid arthritis, and if so to determine the quantitative effect of smoking. Methods: From a cohort (n = 1589) in a structured programme for follow up of newly diagnosed cases of rheumatoid arthritis ( symptoms of swollen joints ( 12 months), 112 individuals with rheumatoid nodules at inclusion were identified. Nodular patients were each compared with two age and sex matched controls without nodules from the same cohort. A detailed self administered tobacco use questionnaire was answered by 210 patients (63%). Results: Seventy patients were current smokers, 71 former smokers, and 69 had never smoked. Current smoking and former smoking were more... (More)
- Objective: To examine whether smoking is a risk factor for rheumatoid nodules in early rheumatoid arthritis, and if so to determine the quantitative effect of smoking. Methods: From a cohort (n = 1589) in a structured programme for follow up of newly diagnosed cases of rheumatoid arthritis ( symptoms of swollen joints ( 12 months), 112 individuals with rheumatoid nodules at inclusion were identified. Nodular patients were each compared with two age and sex matched controls without nodules from the same cohort. A detailed self administered tobacco use questionnaire was answered by 210 patients (63%). Results: Seventy patients were current smokers, 71 former smokers, and 69 had never smoked. Current smoking and former smoking were more common in patients with rheumatoid nodules compared with controls (86% v 59%) in both sexes. Positive rheumatoid factor (RF) was found more often among cases with nodules than controls (78% v 64%). Using detailed information from the questionnaires with conditional logistic regression analyses, ever having smoked was associated with an increased risk of the presence of rheumatoid nodules ( odds ratio ( OR) = 7.3 (95% confidence interval, 2.3 to 23.6); p = 0.001). The risk of having nodules was not obviously dose dependent when smoking duration as well as smoking amount were examined. A stratified analysis showed that only RF positive smokers had an increased risk of rheumatoid nodules. Smoking was associated with rheumatoid nodules among both men ( p = 0.006) and women ( p = 0.001). Tobacco use other than smoking ( n = 31) was not associated with an increased risk of nodules ( OR = 0.8 (0.2 to 3.4); p = 0.813). Conclusions: There is a strong association between smoking and rheumatoid nodules in early seropositive rheumatoid arthritis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/693379
- author
- Nyhall-Wahlin, BM ; Jacobsson, Lennart LU ; Petersson, IF and Turesson, Carl LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of the Rheumatic Diseases
- volume
- 65
- issue
- 5
- pages
- 601 - 606
- publisher
- BMJ Publishing Group
- external identifiers
-
- wos:000236764900008
- pmid:16166104
- scopus:33646265526
- pmid:16166104
- ISSN
- 1468-2060
- DOI
- 10.1136/ard.2005.039172
- language
- English
- LU publication?
- yes
- id
- f334180f-8f4b-4a98-8799-70cd34902d97 (old id 693379)
- date added to LUP
- 2016-04-01 16:37:16
- date last changed
- 2022-04-15 05:55:06
@article{f334180f-8f4b-4a98-8799-70cd34902d97,
abstract = {{Objective: To examine whether smoking is a risk factor for rheumatoid nodules in early rheumatoid arthritis, and if so to determine the quantitative effect of smoking. Methods: From a cohort (n = 1589) in a structured programme for follow up of newly diagnosed cases of rheumatoid arthritis ( symptoms of swollen joints ( 12 months), 112 individuals with rheumatoid nodules at inclusion were identified. Nodular patients were each compared with two age and sex matched controls without nodules from the same cohort. A detailed self administered tobacco use questionnaire was answered by 210 patients (63%). Results: Seventy patients were current smokers, 71 former smokers, and 69 had never smoked. Current smoking and former smoking were more common in patients with rheumatoid nodules compared with controls (86% v 59%) in both sexes. Positive rheumatoid factor (RF) was found more often among cases with nodules than controls (78% v 64%). Using detailed information from the questionnaires with conditional logistic regression analyses, ever having smoked was associated with an increased risk of the presence of rheumatoid nodules ( odds ratio ( OR) = 7.3 (95% confidence interval, 2.3 to 23.6); p = 0.001). The risk of having nodules was not obviously dose dependent when smoking duration as well as smoking amount were examined. A stratified analysis showed that only RF positive smokers had an increased risk of rheumatoid nodules. Smoking was associated with rheumatoid nodules among both men ( p = 0.006) and women ( p = 0.001). Tobacco use other than smoking ( n = 31) was not associated with an increased risk of nodules ( OR = 0.8 (0.2 to 3.4); p = 0.813). Conclusions: There is a strong association between smoking and rheumatoid nodules in early seropositive rheumatoid arthritis.}},
author = {{Nyhall-Wahlin, BM and Jacobsson, Lennart and Petersson, IF and Turesson, Carl}},
issn = {{1468-2060}},
language = {{eng}},
number = {{5}},
pages = {{601--606}},
publisher = {{BMJ Publishing Group}},
series = {{Annals of the Rheumatic Diseases}},
title = {{Smoking is a strong risk factor for rheumatoid nodules in early rheumatoid arthritis}},
url = {{http://dx.doi.org/10.1136/ard.2005.039172}},
doi = {{10.1136/ard.2005.039172}},
volume = {{65}},
year = {{2006}},
}