Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection
(2003) In European Journal of Pharmacology 482(1-3). p.85-94- Abstract
The aim of this study was to characterise the expression of the melanocortin system in the normal and injured rat visual system. Using real-time polymerase chain reaction and immunohistochemistry, we detected melanocortin MC3, MC4 and MC5 receptors and proopiomelanocortin in adult retina and superior colliculus. Melanocortin MC4 receptor mRNA was the most abundant receptor. Melanocortin MC3, MC4 and MC5 receptors were localised to the ganglion cell and inner nuclear layers and the melanocortin MC3 and MC4 receptors were localised to retinal ganglion cells. Transection of the optic nerve leads to ganglion cell death and both melanocortin... (More)
The aim of this study was to characterise the expression of the melanocortin system in the normal and injured rat visual system. Using real-time polymerase chain reaction and immunohistochemistry, we detected melanocortin MC3, MC4 and MC5 receptors and proopiomelanocortin in adult retina and superior colliculus. Melanocortin MC4 receptor mRNA was the most abundant receptor. Melanocortin MC3, MC4 and MC5 receptors were localised to the ganglion cell and inner nuclear layers and the melanocortin MC3 and MC4 receptors were localised to retinal ganglion cells. Transection of the optic nerve leads to ganglion cell death and both melanocortin receptor and proopiomelanocortin expression decreased in superior colliculus after transection whereas the expression was unchanged or even increased in the retina. α-Melanocyte-stimulating hormone elicited neurite outgrowth from embryonic retinal explants. Together, these data implicate a role for the melanocortin system in the adult rat retina and that melanocortins can stimulate neurite growth from retinal neurons.
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- author
- Lindqvist, Niclas LU ; Näpänkangas, Ulla ; Lindblom, Jonas and Hallböök, Finn
- publishing date
- 2003-12-15
- type
- Contribution to journal
- publication status
- published
- keywords
- Axotomy, Injury, Melanocortin receptor, mRNA expression, POMC (proopiomelanocortin), Retina
- in
- European Journal of Pharmacology
- volume
- 482
- issue
- 1-3
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:14660008
- scopus:0345167916
- ISSN
- 0014-2999
- DOI
- 10.1016/j.ejphar.2003.10.011
- language
- English
- LU publication?
- no
- id
- 6957783c-8412-498a-a36d-666bf334db20
- date added to LUP
- 2017-06-02 15:18:12
- date last changed
- 2024-03-31 09:12:05
@article{6957783c-8412-498a-a36d-666bf334db20, abstract = {{<p>The aim of this study was to characterise the expression of the melanocortin system in the normal and injured rat visual system. Using real-time polymerase chain reaction and immunohistochemistry, we detected melanocortin MC<sub>3</sub>, MC<sub>4</sub> and MC<sub>5</sub> receptors and proopiomelanocortin in adult retina and superior colliculus. Melanocortin MC<sub>4</sub> receptor mRNA was the most abundant receptor. Melanocortin MC<sub>3</sub>, MC<sub>4</sub> and MC<sub>5</sub> receptors were localised to the ganglion cell and inner nuclear layers and the melanocortin MC<sub>3</sub> and MC<sub>4</sub> receptors were localised to retinal ganglion cells. Transection of the optic nerve leads to ganglion cell death and both melanocortin receptor and proopiomelanocortin expression decreased in superior colliculus after transection whereas the expression was unchanged or even increased in the retina. α-Melanocyte-stimulating hormone elicited neurite outgrowth from embryonic retinal explants. Together, these data implicate a role for the melanocortin system in the adult rat retina and that melanocortins can stimulate neurite growth from retinal neurons.</p>}}, author = {{Lindqvist, Niclas and Näpänkangas, Ulla and Lindblom, Jonas and Hallböök, Finn}}, issn = {{0014-2999}}, keywords = {{Axotomy; Injury; Melanocortin receptor; mRNA expression; POMC (proopiomelanocortin); Retina}}, language = {{eng}}, month = {{12}}, number = {{1-3}}, pages = {{85--94}}, publisher = {{Elsevier}}, series = {{European Journal of Pharmacology}}, title = {{Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection}}, url = {{http://dx.doi.org/10.1016/j.ejphar.2003.10.011}}, doi = {{10.1016/j.ejphar.2003.10.011}}, volume = {{482}}, year = {{2003}}, }