Transcription factor 7-like 2 (TCF7L2)
(2016) p.297-316- Abstract
In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus in intron 3 of the gene and have helped pinpoint, with relative confidence, the causal lesion at this locus. However, despite this association being beyond doubt, there is still a lack of consensus with respect to mechanisms of action and which tissue(s) it actually exerts its influence on the pathogenesis of type 2 diabetes.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/6debe321-1013-4869-bf3a-4c39e6e858a5
- author
- Grant, Struan F A and Groop, Leif LU
- organization
- publishing date
- 2016-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation
- pages
- 20 pages
- publisher
- Springer International Publishing
- external identifiers
-
- scopus:84978218406
- ISBN
- 9783319015743
- 9783319015736
- DOI
- 10.1007/978-3-319-01574-3_14
- language
- English
- LU publication?
- yes
- id
- 6debe321-1013-4869-bf3a-4c39e6e858a5
- date added to LUP
- 2016-08-10 16:48:01
- date last changed
- 2024-01-04 10:37:27
@inbook{6debe321-1013-4869-bf3a-4c39e6e858a5, abstract = {{<p>In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus in intron 3 of the gene and have helped pinpoint, with relative confidence, the causal lesion at this locus. However, despite this association being beyond doubt, there is still a lack of consensus with respect to mechanisms of action and which tissue(s) it actually exerts its influence on the pathogenesis of type 2 diabetes.</p>}}, author = {{Grant, Struan F A and Groop, Leif}}, booktitle = {{The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation}}, isbn = {{9783319015743}}, language = {{eng}}, month = {{01}}, pages = {{297--316}}, publisher = {{Springer International Publishing}}, title = {{Transcription factor 7-like 2 (TCF7L2)}}, url = {{http://dx.doi.org/10.1007/978-3-319-01574-3_14}}, doi = {{10.1007/978-3-319-01574-3_14}}, year = {{2016}}, }