Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines
(2019) In Angewandte Chemie - International Edition 58(25). p.8551-8555- Abstract
The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/71c42a33-9da8-4a55-9bc4-a81f5be6266b
- author
- Yu, Lu LU and Somfai, Peter LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- amines, copper, enamines, enantioselectivity, hydroamination
- in
- Angewandte Chemie - International Edition
- volume
- 58
- issue
- 25
- pages
- 8551 - 8555
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:30990943
- scopus:85065719860
- ISSN
- 1433-7851
- DOI
- 10.1002/anie.201902642
- language
- English
- LU publication?
- yes
- id
- 71c42a33-9da8-4a55-9bc4-a81f5be6266b
- date added to LUP
- 2019-06-17 11:37:23
- date last changed
- 2024-08-06 21:15:20
@article{71c42a33-9da8-4a55-9bc4-a81f5be6266b, abstract = {{<p>The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.</p>}}, author = {{Yu, Lu and Somfai, Peter}}, issn = {{1433-7851}}, keywords = {{amines; copper; enamines; enantioselectivity; hydroamination}}, language = {{eng}}, number = {{25}}, pages = {{8551--8555}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Angewandte Chemie - International Edition}}, title = {{Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines}}, url = {{http://dx.doi.org/10.1002/anie.201902642}}, doi = {{10.1002/anie.201902642}}, volume = {{58}}, year = {{2019}}, }