URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats.
(2015) In BJU International- Abstract
- To determine if an inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) can counteract the changes in urodynamic parameters and bladder afferent activities induced by intravesical prostaglandin E2 (PGE2 )-instillation, we studied effects of URB937, a peripherally-restricted FAAH inhibitor, on single-unit afferent activity (SAA) during PGE2 -induced bladder overactivity in rats.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7749225
- author
- Aizawa, Naoki ; Gandaglia, Giorgio ; Hedlund, Petter LU ; Fujimura, Tetsuya ; Fukuhara, Hiroshi ; Montorsi, Francesco ; Homma, Yukio and Igawa, Yasuhiko
- organization
- publishing date
- 2015-07-18
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BJU International
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:26189783
- scopus:84940173984
- wos:000374282100024
- pmid:26189783
- ISSN
- 1464-4096
- DOI
- 10.1111/bju.13223
- language
- English
- LU publication?
- yes
- id
- 6d7dc4c3-21bb-4153-9645-9dcb539d21fd (old id 7749225)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26189783?dopt=Abstract
- date added to LUP
- 2016-04-04 08:02:26
- date last changed
- 2022-04-15 19:47:12
@article{6d7dc4c3-21bb-4153-9645-9dcb539d21fd, abstract = {{To determine if an inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) can counteract the changes in urodynamic parameters and bladder afferent activities induced by intravesical prostaglandin E2 (PGE2 )-instillation, we studied effects of URB937, a peripherally-restricted FAAH inhibitor, on single-unit afferent activity (SAA) during PGE2 -induced bladder overactivity in rats.}}, author = {{Aizawa, Naoki and Gandaglia, Giorgio and Hedlund, Petter and Fujimura, Tetsuya and Fukuhara, Hiroshi and Montorsi, Francesco and Homma, Yukio and Igawa, Yasuhiko}}, issn = {{1464-4096}}, language = {{eng}}, month = {{07}}, publisher = {{Wiley-Blackwell}}, series = {{BJU International}}, title = {{URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats.}}, url = {{http://dx.doi.org/10.1111/bju.13223}}, doi = {{10.1111/bju.13223}}, year = {{2015}}, }