Directed vaccination against pneumococcal disease
Li, Yi ; Hill, Andrew ; Beitelshees, Marie ; Shao, Shuai ; Lovell, Jonathan F ; Davidson, Bruce A ; Knight, Paul R ; Hakansson, Anders P LU
; Pfeifer, Blaine A
and Jones, Charles H
(2016)
In Proceedings of the National Academy of Sciences
113(25).
p.6898-6903
- Abstract
Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable... (More)
Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable of multivalent surface display, which can be adapted easily to a changing clinical picture, results include complete protection against the development of pneumonia and sepsis during animal challenge experiments with multiple, highly variable, and clinically relevant pneumococcal isolates. The approach thus offers a unique and dynamic treatment option readily adaptable to other commensal pathogens.
(Less)
- author
- Li, Yi
; Hill, Andrew
; Beitelshees, Marie
; Shao, Shuai
; Lovell, Jonathan F
; Davidson, Bruce A
; Knight, Paul R
; Hakansson, Anders P
LU
; Pfeifer, Blaine A
and Jones, Charles H
- organization
- publishing date
- 2016-06-21
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences
- volume
- 113
- issue
- 25
- pages
- 6 pages
- publisher
- National Academy of Sciences
- external identifiers
-
- scopus:84975761292
- wos:000378272400040
- pmid:27274071
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.1603007113
- language
- English
- LU publication?
- yes
- id
- 77bccb69-2068-4d26-841b-79003b1f1a5b
- date added to LUP
- 2016-06-28 10:17:23
- date last changed
- 2024-04-05 02:58:31
@article{77bccb69-2068-4d26-841b-79003b1f1a5b,
abstract = {{<p>Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable of multivalent surface display, which can be adapted easily to a changing clinical picture, results include complete protection against the development of pneumonia and sepsis during animal challenge experiments with multiple, highly variable, and clinically relevant pneumococcal isolates. The approach thus offers a unique and dynamic treatment option readily adaptable to other commensal pathogens.</p>}},
author = {{Li, Yi and Hill, Andrew and Beitelshees, Marie and Shao, Shuai and Lovell, Jonathan F and Davidson, Bruce A and Knight, Paul R and Hakansson, Anders P and Pfeifer, Blaine A and Jones, Charles H}},
issn = {{1091-6490}},
language = {{eng}},
month = {{06}},
number = {{25}},
pages = {{6898--6903}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences}},
title = {{Directed vaccination against pneumococcal disease}},
url = {{https://lup.lub.lu.se/search/files/17055459/8932499.pdf}},
doi = {{10.1073/pnas.1603007113}},
volume = {{113}},
year = {{2016}},
}