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Complementarity-determining region (CDR) implantation : A theme of recombination

Söderlind, Eskil LU ; Ohlin, Mats LU orcid and Carlsson, Roland LU (1999) In Immunotechnology 4(3-4). p.279-285
Abstract

A novel technology in the area of antibody engineering has been developed which allows for the creation of new types of antibody molecules. It is called complementarity-determining region (CDR) implantation and permits the random combination of CDR sequences formed in vivo into a single master framework. Thus, totally new gene combinations can be produced and used in selection processes. The result is a genetic variability which is extremely large, even exceeding the natural variability found in the immune system. In this commentary, CDR implantation is presented and the technology is discussed.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Antibody engineering, CDR implantation, Complementarity-determining region, Genetic variation
in
Immunotechnology
volume
4
issue
3-4
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:10231097
  • scopus:0033103199
ISSN
1380-2933
DOI
10.1016/S1380-2933(98)00027-X
language
English
LU publication?
yes
id
79b433e1-c0f9-4e10-b092-3e9503d4b425
date added to LUP
2016-04-19 14:04:18
date last changed
2024-01-03 23:58:07
@article{79b433e1-c0f9-4e10-b092-3e9503d4b425,
  abstract     = {{<p>A novel technology in the area of antibody engineering has been developed which allows for the creation of new types of antibody molecules. It is called complementarity-determining region (CDR) implantation and permits the random combination of CDR sequences formed in vivo into a single master framework. Thus, totally new gene combinations can be produced and used in selection processes. The result is a genetic variability which is extremely large, even exceeding the natural variability found in the immune system. In this commentary, CDR implantation is presented and the technology is discussed.</p>}},
  author       = {{Söderlind, Eskil and Ohlin, Mats and Carlsson, Roland}},
  issn         = {{1380-2933}},
  keywords     = {{Antibody engineering; CDR implantation; Complementarity-determining region; Genetic variation}},
  language     = {{eng}},
  number       = {{3-4}},
  pages        = {{279--285}},
  publisher    = {{Elsevier}},
  series       = {{Immunotechnology}},
  title        = {{Complementarity-determining region (CDR) implantation : A theme of recombination}},
  url          = {{http://dx.doi.org/10.1016/S1380-2933(98)00027-X}},
  doi          = {{10.1016/S1380-2933(98)00027-X}},
  volume       = {{4}},
  year         = {{1999}},
}