Localization-triggered bacterial pathogenesis.
Lood, Rolf LU ; Wollein Waldetoft, Kristofer LU and Nordenfelt, Pontus LU
(2015)
In Future Microbiology
10(10).
p.1659-1668
- Abstract
- Bacterial infections are becoming an increasing problem worldwide and there is a need for a deeper understanding of how bacteria turn pathogenic. Here, we suggest that one answer may be found by taking into account the localization of the bacteria, both at an anatomical level and at a microenvironment level. Both commensals and traditional pathogens alter their interaction with the human host depending on the local surroundings - turning either more or less virulent. These localization effects could derive from the characteristics of different anatomical sites but also from local differences within a microenvironment. In order to understand the adaptive functions of bacterial virulence factors, we need to study the bacteria in the... (More)
- Bacterial infections are becoming an increasing problem worldwide and there is a need for a deeper understanding of how bacteria turn pathogenic. Here, we suggest that one answer may be found by taking into account the localization of the bacteria, both at an anatomical level and at a microenvironment level. Both commensals and traditional pathogens alter their interaction with the human host depending on the local surroundings - turning either more or less virulent. These localization effects could derive from the characteristics of different anatomical sites but also from local differences within a microenvironment. In order to understand the adaptive functions of bacterial virulence factors, we need to study the bacteria in the environments where they have evolved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8158907
- author
- Lood, Rolf
LU
; Wollein Waldetoft, Kristofer
LU
and Nordenfelt, Pontus
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Future Microbiology
- volume
- 10
- issue
- 10
- pages
- 1659 - 1668
- publisher
- Future Medicine Ltd.
- external identifiers
-
- pmid:26437846
- wos:000363282500011
- scopus:84945249063
- pmid:26437846
- ISSN
- 1746-0921
- DOI
- 10.2217/fmb.15.89
- language
- English
- LU publication?
- yes
- id
- 3136d002-d4f0-4372-90ed-89d4e61da339 (old id 8158907)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26437846?dopt=Abstract
- date added to LUP
- 2016-04-01 10:09:40
- date last changed
- 2023-04-03 04:11:27
@article{3136d002-d4f0-4372-90ed-89d4e61da339,
abstract = {{Bacterial infections are becoming an increasing problem worldwide and there is a need for a deeper understanding of how bacteria turn pathogenic. Here, we suggest that one answer may be found by taking into account the localization of the bacteria, both at an anatomical level and at a microenvironment level. Both commensals and traditional pathogens alter their interaction with the human host depending on the local surroundings - turning either more or less virulent. These localization effects could derive from the characteristics of different anatomical sites but also from local differences within a microenvironment. In order to understand the adaptive functions of bacterial virulence factors, we need to study the bacteria in the environments where they have evolved.}},
author = {{Lood, Rolf and Wollein Waldetoft, Kristofer and Nordenfelt, Pontus}},
issn = {{1746-0921}},
language = {{eng}},
number = {{10}},
pages = {{1659--1668}},
publisher = {{Future Medicine Ltd.}},
series = {{Future Microbiology}},
title = {{Localization-triggered bacterial pathogenesis.}},
url = {{https://lup.lub.lu.se/search/files/1615445/8862857.pdf}},
doi = {{10.2217/fmb.15.89}},
volume = {{10}},
year = {{2015}},
}