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Instantaneous Wave-Free Ratio versus Fractional Flow Reserve guided intervention (iFR-SWEDEHEART): Rationale and design of a multicenter, prospective, registry-based randomized clinical trial.

Götberg, Matthias LU ; Christiansen, Evald H ; Gudmundsdottir, Ingibjörg ; Sandhall, Lennart ; Omerovic, Elmir ; James, Stefan K ; Erlinge, David LU orcid and Fröbert, Ole (2015) In American Heart Journal 170(5). p.945-950
Abstract
Instantaneous wave-free ratio (iFR) is a new hemodynamic resting index for assessment of coronary artery stenosis severity. iFR uses high frequency sampling to calculate a gradient across a coronary lesion during a period of diastole. The index has been tested against fractional flow reserve (FFR) and found to have an overall classification agreement of 80% to 85%. Whether the level of disagreement is clinically relevant is unknown. Clinical outcome data on iFR are scarce. This study is a registry-based randomized clinical trial, which is a novel strategy using health quality registries as on-line platforms for randomization, case record forms, and follow-up.
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Heart Journal
volume
170
issue
5
pages
945 - 950
publisher
Mosby-Elsevier
external identifiers
  • pmid:26542503
  • wos:000364434600015
  • scopus:84954229158
  • pmid:26542503
ISSN
1097-6744
DOI
10.1016/j.ahj.2015.07.031
language
English
LU publication?
yes
id
ce5b0a38-8a7b-4838-aa28-ed6333b0e9ed (old id 8243018)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26542503?dopt=Abstract
date added to LUP
2016-04-01 10:54:26
date last changed
2022-03-20 01:10:17
@article{ce5b0a38-8a7b-4838-aa28-ed6333b0e9ed,
  abstract     = {{Instantaneous wave-free ratio (iFR) is a new hemodynamic resting index for assessment of coronary artery stenosis severity. iFR uses high frequency sampling to calculate a gradient across a coronary lesion during a period of diastole. The index has been tested against fractional flow reserve (FFR) and found to have an overall classification agreement of 80% to 85%. Whether the level of disagreement is clinically relevant is unknown. Clinical outcome data on iFR are scarce. This study is a registry-based randomized clinical trial, which is a novel strategy using health quality registries as on-line platforms for randomization, case record forms, and follow-up.}},
  author       = {{Götberg, Matthias and Christiansen, Evald H and Gudmundsdottir, Ingibjörg and Sandhall, Lennart and Omerovic, Elmir and James, Stefan K and Erlinge, David and Fröbert, Ole}},
  issn         = {{1097-6744}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{945--950}},
  publisher    = {{Mosby-Elsevier}},
  series       = {{American Heart Journal}},
  title        = {{Instantaneous Wave-Free Ratio versus Fractional Flow Reserve guided intervention (iFR-SWEDEHEART): Rationale and design of a multicenter, prospective, registry-based randomized clinical trial.}},
  url          = {{http://dx.doi.org/10.1016/j.ahj.2015.07.031}},
  doi          = {{10.1016/j.ahj.2015.07.031}},
  volume       = {{170}},
  year         = {{2015}},
}