Investigation of cerebrospinal fluid flow in the cerebral aqueduct using high-resolution phase contrast measurements at 7T MRI
(2018) In Acta Radiologica 59(8). p.988-996- Abstract
Background: The cerebral aqueduct is a central conduit for cerebrospinal fluid (CSF), and non-invasive quantification of CSF flow in the aqueduct may be an important tool for diagnosis and follow-up of treatment. Magnetic resonance (MR) methods at clinical field strengths are limited by low spatial resolution. Purpose: To investigate the feasibility of high-resolution through-plane MR flow measurements (2D-PC) in the cerebral aqueduct at high field strength (7T). Material and Methods: 2D-PC measurements in the aqueduct were performed in nine healthy individuals at 7T. Measurement accuracy was determined using a phantom. Aqueduct area, mean velocity, maximum velocity, minimum velocity, net flow, and mean flow were determined using... (More)
Background: The cerebral aqueduct is a central conduit for cerebrospinal fluid (CSF), and non-invasive quantification of CSF flow in the aqueduct may be an important tool for diagnosis and follow-up of treatment. Magnetic resonance (MR) methods at clinical field strengths are limited by low spatial resolution. Purpose: To investigate the feasibility of high-resolution through-plane MR flow measurements (2D-PC) in the cerebral aqueduct at high field strength (7T). Material and Methods: 2D-PC measurements in the aqueduct were performed in nine healthy individuals at 7T. Measurement accuracy was determined using a phantom. Aqueduct area, mean velocity, maximum velocity, minimum velocity, net flow, and mean flow were determined using in-plane resolutions 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm2. Feasibility criteria were defined based on scan time and spatial and temporal resolution. Results: Phantom validation of 2D-PC MR showed good accuracy. In vivo, stroke volume was −8.2 ± 4.4, −4.7 ± 2.8, −6.0 ± 3.8, and −3.7 ± 2.1 µL for 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm2, respectively. The scan with 0.3 × 0.3 mm2 resolution fulfilled the feasibility criteria for a wide range of heart rates and aqueduct diameters. Conclusion: 7T MR enables non-invasive quantification of CSF flow and velocity in the cerebral aqueduct with high spatial resolution.
(Less)
- author
- Markenroth Bloch, Karin LU ; Töger, Johannes LU and Ståhlberg, Freddy LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cerebral aqueduct, cerebrospinal fluid, magnetic resonance imaging, pulsatile flow
- in
- Acta Radiologica
- volume
- 59
- issue
- 8
- pages
- 988 - 996
- publisher
- SAGE Publications
- external identifiers
-
- pmid:29141450
- scopus:85046032788
- ISSN
- 0284-1851
- DOI
- 10.1177/0284185117740762
- language
- English
- LU publication?
- yes
- id
- 828d2611-8ff8-492c-af5c-719132602e4b
- date added to LUP
- 2018-05-16 15:30:38
- date last changed
- 2024-09-16 21:43:03
@article{828d2611-8ff8-492c-af5c-719132602e4b, abstract = {{<p>Background: The cerebral aqueduct is a central conduit for cerebrospinal fluid (CSF), and non-invasive quantification of CSF flow in the aqueduct may be an important tool for diagnosis and follow-up of treatment. Magnetic resonance (MR) methods at clinical field strengths are limited by low spatial resolution. Purpose: To investigate the feasibility of high-resolution through-plane MR flow measurements (2D-PC) in the cerebral aqueduct at high field strength (7T). Material and Methods: 2D-PC measurements in the aqueduct were performed in nine healthy individuals at 7T. Measurement accuracy was determined using a phantom. Aqueduct area, mean velocity, maximum velocity, minimum velocity, net flow, and mean flow were determined using in-plane resolutions 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm<sup>2</sup>. Feasibility criteria were defined based on scan time and spatial and temporal resolution. Results: Phantom validation of 2D-PC MR showed good accuracy. In vivo, stroke volume was −8.2 ± 4.4, −4.7 ± 2.8, −6.0 ± 3.8, and −3.7 ± 2.1 µL for 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm<sup>2</sup>, respectively. The scan with 0.3 × 0.3 mm<sup>2</sup> resolution fulfilled the feasibility criteria for a wide range of heart rates and aqueduct diameters. Conclusion: 7T MR enables non-invasive quantification of CSF flow and velocity in the cerebral aqueduct with high spatial resolution.</p>}}, author = {{Markenroth Bloch, Karin and Töger, Johannes and Ståhlberg, Freddy}}, issn = {{0284-1851}}, keywords = {{Cerebral aqueduct; cerebrospinal fluid; magnetic resonance imaging; pulsatile flow}}, language = {{eng}}, number = {{8}}, pages = {{988--996}}, publisher = {{SAGE Publications}}, series = {{Acta Radiologica}}, title = {{Investigation of cerebrospinal fluid flow in the cerebral aqueduct using high-resolution phase contrast measurements at 7T MRI}}, url = {{http://dx.doi.org/10.1177/0284185117740762}}, doi = {{10.1177/0284185117740762}}, volume = {{59}}, year = {{2018}}, }